Immunoreactive insulin levels are elevated in the cerebrospinal fluid of genetically obese zucker rats

Leslie J. Stein; Daniel M. Dorsa; Denis G. Askin; Dianne P. Figlewicz; Hitoshi Ikeda; Sandra P. Rarikmann; M. R.C. Greenwood; Daniel Porte; Stephen C. Woods

doi:10.1210/endo-113-6-2299

Immunoreactive insulin levels are elevated in the cerebrospinal fluid of genetically obese zucker rats

Leslie J. Stein, Daniel M. Dorsa, Denis G. Askin, Dianne P. Figlewicz, Hitoshi Ikeda, Sandra P. Rarikmann, M. R.C. Greenwood, Daniel Porte, Stephen C. Woods

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Abstract

Immunoreactive insulin (IRI) concentrations were measured in plasma and cerebrospinal fluid (CSF) of four-month old genetically obese Zucker rats, their heterozygote lean littermates, and age-matched normalweight Wistar rats. Basal plasma IRI was 201 ± 35 uU/ml (X ± SEM) in the obese animals and was significantly elevated compared to both lean Zucker rats (18 ± 2.4 μg/ml, P<0.001) and Wistar rats (12 ± 2.4 μg/ml, P<0.001). The mean CSF IRI concentration of fasted obese Zucker rats was 1.59 ± 0.19 μg/ml; this was significantly higher than the CSF IRI level of either fasted Zucker lean rats (0.31 ± 0.08 μg/ml, P<0.001) or Wistar rats.

Original language	English (US)
Pages (from-to)	2299-2301
Number of pages	3
Journal	Endocrinology
Volume	113
Issue number	6
DOIs	https://doi.org/10.1210/endo-113-6-2299
State	Published - Dec 1983
Externally published	Yes

ASJC Scopus subject areas

Endocrinology

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@article{c20917d378e9425db36afa843363e1b5,

title = "Immunoreactive insulin levels are elevated in the cerebrospinal fluid of genetically obese zucker rats",

abstract = "Immunoreactive insulin (IRI) concentrations were measured in plasma and cerebrospinal fluid (CSF) of four-month old genetically obese Zucker rats, their heterozygote lean littermates, and age-matched normalweight Wistar rats. Basal plasma IRI was 201 ± 35 uU/ml (X ± SEM) in the obese animals and was significantly elevated compared to both lean Zucker rats (18 ± 2.4 μg/ml, P<0.001) and Wistar rats (12 ± 2.4 μg/ml, P<0.001). The mean CSF IRI concentration of fasted obese Zucker rats was 1.59 ± 0.19 μg/ml; this was significantly higher than the CSF IRI level of either fasted Zucker lean rats (0.31 ± 0.08 μg/ml, P<0.001) or Wistar rats.",

author = "Stein, {Leslie J.} and Dorsa, {Daniel M.} and Askin, {Denis G.} and Figlewicz, {Dianne P.} and Hitoshi Ikeda and Rarikmann, {Sandra P.} and Greenwood, {M. R.C.} and Daniel Porte and Woods, {Stephen C.}",

year = "1983",

month = dec,

doi = "10.1210/endo-113-6-2299",

language = "English (US)",

volume = "113",

pages = "2299--2301",

journal = "Endocrinology",

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publisher = "The Endocrine Society",

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T1 - Immunoreactive insulin levels are elevated in the cerebrospinal fluid of genetically obese zucker rats

AU - Stein, Leslie J.

AU - Dorsa, Daniel M.

AU - Askin, Denis G.

AU - Figlewicz, Dianne P.

AU - Ikeda, Hitoshi

AU - Rarikmann, Sandra P.

AU - Greenwood, M. R.C.

AU - Porte, Daniel

AU - Woods, Stephen C.

PY - 1983/12

Y1 - 1983/12

N2 - Immunoreactive insulin (IRI) concentrations were measured in plasma and cerebrospinal fluid (CSF) of four-month old genetically obese Zucker rats, their heterozygote lean littermates, and age-matched normalweight Wistar rats. Basal plasma IRI was 201 ± 35 uU/ml (X ± SEM) in the obese animals and was significantly elevated compared to both lean Zucker rats (18 ± 2.4 μg/ml, P<0.001) and Wistar rats (12 ± 2.4 μg/ml, P<0.001). The mean CSF IRI concentration of fasted obese Zucker rats was 1.59 ± 0.19 μg/ml; this was significantly higher than the CSF IRI level of either fasted Zucker lean rats (0.31 ± 0.08 μg/ml, P<0.001) or Wistar rats.

AB - Immunoreactive insulin (IRI) concentrations were measured in plasma and cerebrospinal fluid (CSF) of four-month old genetically obese Zucker rats, their heterozygote lean littermates, and age-matched normalweight Wistar rats. Basal plasma IRI was 201 ± 35 uU/ml (X ± SEM) in the obese animals and was significantly elevated compared to both lean Zucker rats (18 ± 2.4 μg/ml, P<0.001) and Wistar rats (12 ± 2.4 μg/ml, P<0.001). The mean CSF IRI concentration of fasted obese Zucker rats was 1.59 ± 0.19 μg/ml; this was significantly higher than the CSF IRI level of either fasted Zucker lean rats (0.31 ± 0.08 μg/ml, P<0.001) or Wistar rats.

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JO - Endocrinology

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IS - 6

ER -

Immunoreactive insulin levels are elevated in the cerebrospinal fluid of genetically obese zucker rats

Abstract

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