TY - JOUR
T1 - Immunosuppression by phenytoin
T2 - Implication for altered immune competence in brain-tumor patients
AU - Kikuchi, K.
AU - McCormick, C. I.
AU - Neuwelt, E. A.
PY - 1984
Y1 - 1984
N2 - This investigation was conducted to examine the immunosuppressive potential of phenytoin in vivo and to document a correlation between phenytoin therapy and depressed lymphocyte responsiveness to mitogens. It was thought that phenytoin, the most widely used anticonvulsant agent, may play some role in the immunosuppression seen in brain-tumor patients. The effect of phenytoin on mitogen-stimulated lymphocyte function was evaluated by tritiated (3H)-thymidine incorporation and lymphocyte nuclear size distribution. Lymphocytes from either phenytoin-treated or normal rabbits were incubated for 90 hours in culture medium in the presence of 3 mitogens: phytohemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM). Significant suppression of mitogen-induced activation of the lymphocytes from treated animals was demonstrated. The present studies suggest a possible connection beween phenytoin therapy and altered immune competence in brain-tumor patients.
AB - This investigation was conducted to examine the immunosuppressive potential of phenytoin in vivo and to document a correlation between phenytoin therapy and depressed lymphocyte responsiveness to mitogens. It was thought that phenytoin, the most widely used anticonvulsant agent, may play some role in the immunosuppression seen in brain-tumor patients. The effect of phenytoin on mitogen-stimulated lymphocyte function was evaluated by tritiated (3H)-thymidine incorporation and lymphocyte nuclear size distribution. Lymphocytes from either phenytoin-treated or normal rabbits were incubated for 90 hours in culture medium in the presence of 3 mitogens: phytohemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM). Significant suppression of mitogen-induced activation of the lymphocytes from treated animals was demonstrated. The present studies suggest a possible connection beween phenytoin therapy and altered immune competence in brain-tumor patients.
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U2 - 10.3171/jns.1984.61.6.1085
DO - 10.3171/jns.1984.61.6.1085
M3 - Article
C2 - 6502237
AN - SCOPUS:0021716897
SN - 0022-3085
VL - 61
SP - 1085
EP - 1090
JO - Journal of neurosurgery
JF - Journal of neurosurgery
IS - 6
ER -