Abstract
Objective: To assess outcomes in twin-twin transfusion syndrome (TTTS) according to middle cerebral artery pulsatility index (MCA-PI) prior to fetoscopic laser photocoagulation (FLPC) surgery. Methods: A retrospective cohort analysis of monochorionic-twin pregnancies complicated by TTTS who underwent FLPC at two fetal centers (2012–2021). The cohort was stratified according to abnormal MCA-PI of the donor twin, defined as below fifth centile for gestational age. Results: Abnormal MCA-PI of the donor twin was detected in 46 (17.7%) cases compared to 213 (83.3%) controls with no such abnormality. The abnormal PI group presented with higher rates of sFGR (56.5% vs. 36.8% in controls, p = 0.014) and lower donor survival rates within 48 h after FLPC (73.9 vs. 86.8%, p = 0.029). Donor twin survival rates at the time of delivery and 30 days after birth were lower in the abnormal MCA-PI. Multivariate logistic regression analysis controlling for sFGR and MCA-PI <fifth centile demonstrated the latter to be independently associated with lower survival rates at the time of delivery and 30 days after birth [OR = 0.497 95%CI (0.250–0.986) p = 0.045, and OR = 0.499 95%CI (0.252–0.986), p = 0.046, respectively]. Recipient's survival rates did not differ between the groups. Conclusions: Donor survival at the time of delivery and 30 days after birth was lower in TTTS cases with MCA-PI<fifth centile for gestational age prior to laser surgery. This parameter may be considered when evaluating prognosis for TTTS.
Original language | English (US) |
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Pages (from-to) | 102-108 |
Number of pages | 7 |
Journal | Prenatal Diagnosis |
Volume | 43 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2023 |
Externally published | Yes |
ASJC Scopus subject areas
- Obstetrics and Gynecology
- Genetics(clinical)