Abstract
The viral infectivity factor (Vif) of human immunodeficiency virus type 1 (HIV-1) neutralizes an unidentified antiviral pathway that occurs only in nonpermissive (NP) cells. Using a yeast two-hybrid screen of a human lymphocyte cDNA library, we identified several potential Vif partners. One, the nuclear body protein Sp140, was found specifically in all NP cells (n = 12 cell lines tested; P ≤ 0.001), and HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif. Our results implicate Spl40 in a response to HIV-1 that may be related to or coordinated with the pathway that inactivates HIV-1 lacking vif.
Original language | English (US) |
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Pages (from-to) | 11133-11138 |
Number of pages | 6 |
Journal | Journal of virology |
Volume | 76 |
Issue number | 21 |
DOIs | |
State | Published - Nov 2002 |
Externally published | Yes |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology