Abstract
Iatrogenic nerve injury represents one of the most feared surgical complications and remains a major morbidity across many surgical specialties. Currently, no clinically approved technique can directly enhance intraoperative nerve visualization, where intraoperative nerve identification continues to challenge even experienced surgeons. Fluorescence-guided surgery (FGS) has been successfully integrated into clinical medicine to improve safety and efficacy in the surgical arena. A number of tissue- and disease-specific contrast agents are in the clinical translation pipeline for future FGS integration. Within this context, a diverse repertoire of fluorescent tracers have been developed to improve surgeons’ intraoperative vision. This review aims to convey the recent developments for nerve-specific FGS and its potential for clinical translation.
Original language | English (US) |
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Article number | 102361 |
Journal | Current Opinion in Chemical Biology |
Volume | 76 |
DOIs | |
State | Published - Oct 2023 |
Keywords
- Fluorescence-guided surgery
- Fluorescent contrast agents
- Imaging
- Nerve-specific fluorophores
- Optical probes
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry