TY - JOUR
T1 - In vivo functional imaging of blood flow and wall strain rate in outflow tract of embryonic chick heart using ultrafast spectral domain optical coherence tomography
AU - Li, Peng
AU - Yin, Xin
AU - Shi, Liang
AU - Rugonyi, Sandra
AU - Wang, Ruikang K.
N1 - Funding Information:
This work was supported in part by NIH Grants, R01HL094570 and R01HL093140, from the National Heart, Blood and Lung Institute. The authors also acknowledge the assistance of Dr. Lei Shi, Mr. Lin An, and Mr. Zhongwei Zhi for the construction of the OCT system used in this study and their helpful discussions of the results presented in this manuscript.
PY - 2012/9
Y1 - 2012/9
N2 - During cardiac development, the cardiac wall and flowing blood are two important cardiac tissues that constantly interact with each other. This dynamic interaction defines appropriate biomechanical environment to which the embryonic heart is exposed. Quantitative assessment of the dynamic parameters of wall tissues and blood flow is required to further our understanding of cardiac development. We report the use of an ultrafast 1310-nm dual-camera spectral domain optical coherence tomography (SDOCT) system to characterize/image, in parallel, the dynamic radial strain rate of the myocardial wall and the Doppler velocity of the underlying flowing blood within an in vivo beating chick embryo. The OCT system operates at 184-kHz line scan rate, providing the flexibility of imaging the fast blood flow and the slow tissue deformation within one scan. The ability to simultaneously characterize tissue motion and blood flow provides a useful approach to better understand cardiac dynamics during early developmental stages.
AB - During cardiac development, the cardiac wall and flowing blood are two important cardiac tissues that constantly interact with each other. This dynamic interaction defines appropriate biomechanical environment to which the embryonic heart is exposed. Quantitative assessment of the dynamic parameters of wall tissues and blood flow is required to further our understanding of cardiac development. We report the use of an ultrafast 1310-nm dual-camera spectral domain optical coherence tomography (SDOCT) system to characterize/image, in parallel, the dynamic radial strain rate of the myocardial wall and the Doppler velocity of the underlying flowing blood within an in vivo beating chick embryo. The OCT system operates at 184-kHz line scan rate, providing the flexibility of imaging the fast blood flow and the slow tissue deformation within one scan. The ability to simultaneously characterize tissue motion and blood flow provides a useful approach to better understand cardiac dynamics during early developmental stages.
KW - cardiac development
KW - embryonic chick heart
KW - myocardial strain
KW - optical coherence tomography
KW - phase resolved measurement
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U2 - 10.1117/1.JBO.17.9.096006
DO - 10.1117/1.JBO.17.9.096006
M3 - Article
C2 - 23085907
AN - SCOPUS:84869144655
SN - 1083-3668
VL - 17
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 9
M1 - 096006
ER -