Abstract
Purpose: Keratic precipitates (KP) are a common feature of uveitis. We prospectively examined KP with the Heidelberg Retinal Tomograph II confocal laser scanning microscope and Rostock Corneal Module (HRT-RCM) to explore their diagnostic implications. Methods: Prospective, observational, multicenter study. HRT-RCM images were classified by two masked observers. Results: 120 scans on 120 eyes from 110 subjects were included. The majority (N = 93) had non-infectious uveitis. Sixty eyes had active disease at scanning. Eight KP morphologies were defined. Agreement between the two masked graders was high (Kappa value across all categories = 0.81). Cluster and nodular KP were associated with active infectious uveitis (p < 0.01): patients with cluster KP (odds ratio [OR] = 3.03, 95% confidence interval [CI]: 1.43, 6.45) and nodular KP (OR = 3.89, 95% CI: 1.42, 10.65) were more likely to have infectious uveitis than those without. Conclusions: Laser confocal microscopy of KP may have a role in determining between infectious and non-infectious uveitis.
Original language | English (US) |
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Pages (from-to) | 900-909 |
Number of pages | 10 |
Journal | Ocular Immunology and Inflammation |
Volume | 26 |
Issue number | 6 |
DOIs | |
State | Published - Aug 18 2018 |
Keywords
- Confocal microscopy
- imaging analysis
- keratic precipitates
- uveitis
ASJC Scopus subject areas
- Immunology and Allergy
- Ophthalmology