TY - JOUR
T1 - Inactivation of the ciaH gene in Streptococcus mutans diminishes mutacin production and competence development, alters sucrose-dependent biofilm formation, and reduces stress tolerance
AU - Qi, Fengxia
AU - Merritt, Justin
AU - Lux, Renate
AU - Shi, Wenyuan
PY - 2004/8
Y1 - 2004/8
N2 - Many clinical isolates of Streptococcus mutans produce peptide antibiotics called mutacins. Mutacin production may play an important role in the ecology of S. mutans in dental plaque. In this study, inactivation of a histidine kinase gene, ciaH, abolished mutacin production. Surprisingly, the same mutation also diminished competence development, stress tolerance, and sucrose-dependent biofilm formation.
AB - Many clinical isolates of Streptococcus mutans produce peptide antibiotics called mutacins. Mutacin production may play an important role in the ecology of S. mutans in dental plaque. In this study, inactivation of a histidine kinase gene, ciaH, abolished mutacin production. Surprisingly, the same mutation also diminished competence development, stress tolerance, and sucrose-dependent biofilm formation.
UR - http://www.scopus.com/inward/record.url?scp=3342944909&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3342944909&partnerID=8YFLogxK
U2 - 10.1128/IAI.72.8.4895-4899.2004
DO - 10.1128/IAI.72.8.4895-4899.2004
M3 - Article
C2 - 15271957
AN - SCOPUS:3342944909
SN - 0019-9567
VL - 72
SP - 4895
EP - 4899
JO - Infection and Immunity
JF - Infection and Immunity
IS - 8
ER -