TY - JOUR
T1 - Incidence of refeeding syndrome in children with failure to thrive
AU - Coe, Megan E.
AU - Castellano, Lucinda
AU - Elliott, Megan
AU - Reyes, Joshua
AU - Mendoza, Joanne
AU - Cheney, Debbie
AU - Gardner, Tiffany
AU - Austin, Jared P.
AU - Lee, Clifton C.
N1 - Publisher Copyright:
Copyright © 2020 by the American Academy of Pediatrics
PY - 2020/12/1
Y1 - 2020/12/1
N2 - OBJECTIVES: To determine the incidence of refeeding syndrome in otherwise healthy children,3 years of age admitted for failure to thrive (FTT). METHODS: A multicenter retrospective cohort study was performed on patients aged #36 months admitted with a primary diagnosis of FTT from January 1, 2011, to December 31, 2016. The primary outcome measure was the percentage of patients with laboratory evidence of refeeding syndrome. Exclusion criteria included admission to an ICU, parenteral nutrition, history of prematurity, gastrostomy tube feeds, and any complex chronic conditions. RESULTS: Of the 179 patients meeting inclusion criteria, none had laboratory evidence of refeeding syndrome. Of these, 145 (81%) had laboratory work done at the time of admission, and 69 (39%) had laboratory work repeated after admission. A small percentage (6%) of included patients experienced an adverse event due to repeat laboratory draw. CONCLUSIONS: In otherwise healthy hospitalized patients,3 years of age with a primary diagnosis of FTT, routine laboratory monitoring for electrolyte derangements did not reveal any cases of refeeding syndrome. More robust studies are needed to determine the safety and feasibility of applying low-risk guidelines to this patient population to reduce practice variability and eliminate unnecessary laboratory evaluation and monitoring.
AB - OBJECTIVES: To determine the incidence of refeeding syndrome in otherwise healthy children,3 years of age admitted for failure to thrive (FTT). METHODS: A multicenter retrospective cohort study was performed on patients aged #36 months admitted with a primary diagnosis of FTT from January 1, 2011, to December 31, 2016. The primary outcome measure was the percentage of patients with laboratory evidence of refeeding syndrome. Exclusion criteria included admission to an ICU, parenteral nutrition, history of prematurity, gastrostomy tube feeds, and any complex chronic conditions. RESULTS: Of the 179 patients meeting inclusion criteria, none had laboratory evidence of refeeding syndrome. Of these, 145 (81%) had laboratory work done at the time of admission, and 69 (39%) had laboratory work repeated after admission. A small percentage (6%) of included patients experienced an adverse event due to repeat laboratory draw. CONCLUSIONS: In otherwise healthy hospitalized patients,3 years of age with a primary diagnosis of FTT, routine laboratory monitoring for electrolyte derangements did not reveal any cases of refeeding syndrome. More robust studies are needed to determine the safety and feasibility of applying low-risk guidelines to this patient population to reduce practice variability and eliminate unnecessary laboratory evaluation and monitoring.
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U2 - 10.1542/hpeds.2020-0124
DO - 10.1542/hpeds.2020-0124
M3 - Article
C2 - 33168566
AN - SCOPUS:85133681509
SN - 2154-1663
VL - 10
SP - 1096
EP - 1101
JO - Hospital pediatrics
JF - Hospital pediatrics
IS - 12
ER -