TY - JOUR
T1 - Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program
AU - of program collaborators for Environmental influences on Child Health Outcomes
AU - Miller, Rachel L.
AU - Schuh, Holly
AU - Chandran, Aruna
AU - Aris, Izzuddin M.
AU - Bendixsen, Casper
AU - Blossom, Jeffrey
AU - Breton, Carrie
AU - Camargo, Carlos A.
AU - Canino, Glorisa
AU - Carroll, Kecia N.
AU - Commodore, Sarah
AU - Cordero, José F.
AU - Dabelea, Dana M.
AU - Ferrara, Assiamira
AU - Fry, Rebecca C.
AU - Ganiban, Jody M.
AU - Gern, James E.
AU - Gilliland, Frank D.
AU - Gold, Diane R.
AU - Habre, Rima
AU - Hare, Marion E.
AU - Harte, Robyn N.
AU - Hartert, Tina
AU - Hasegawa, Kohei
AU - Khurana Hershey, Gurjit K.
AU - Jackson, Daniel J.
AU - Joseph, Christine
AU - Kerver, Jean M.
AU - Kim, Haejin
AU - Litonjua, Augusto A.
AU - Marsit, Carmen J.
AU - McEvoy, Cindy
AU - Mendonça, Eneida A.
AU - Moore, Paul E.
AU - Nkoy, Flory L.
AU - O'Connor, Thomas G.
AU - Oken, Emily
AU - Ownby, Dennis
AU - Perzanowski, Matthew
AU - Rivera-Spoljaric, Katherine
AU - Ryan, Patrick H.
AU - Singh, Anne Marie
AU - Stanford, Joseph B.
AU - Wright, Rosalind J.
AU - Wright, Robert O.
AU - Zanobetti, Antonella
AU - Zoratti, Edward
AU - Johnson, Christine C.
AU - Smith, P. B.
AU - Newby, K. L.
N1 - Publisher Copyright:
© 2023 American Academy of Allergy, Asthma & Immunology
PY - 2023/7
Y1 - 2023/7
N2 - Background: Descriptive epidemiological data on incidence rates (IRs) of asthma with recurrent exacerbations (ARE) are sparse. Objectives: This study hypothesized that IRs for ARE would vary by time, geography, age, and race and ethnicity, irrespective of parental asthma history. Methods: The investigators leveraged data from 17,246 children born after 1990 enrolled in 59 US with 1 Puerto Rican cohort in the Environmental Influences on Child Health Outcomes (ECHO) consortium to estimate IRs for ARE. Results: The overall crude IR for ARE was 6.07 per 1000 person-years (95% CI: 5.63-6.51) and was highest for children aged 2-4 years, for Hispanic Black and non-Hispanic Black children, and for those with a parental history of asthma. ARE IRs were higher for 2- to 4-year-olds in each race and ethnicity category and for both sexes. Multivariable analysis confirmed higher adjusted ARE IRs (aIRRs) for children born 2000-2009 compared with those born 1990-1999 and 2010-2017, 2-4 versus 10-19 years old (aIRR = 15.36; 95% CI: 12.09-19.52), and for males versus females (aIRR = 1.34; 95% CI 1.16-1.55). Black children (non-Hispanic and Hispanic) had higher rates than non-Hispanic White children (aIRR = 2.51; 95% CI 2.10-2.99; and aIRR = 2.04; 95% CI: 1.22-3.39, respectively). Children born in the Midwest, Northeast and South had higher rates than those born in the West (P < .01 for each comparison). Children with a parental history of asthma had rates nearly 3 times higher than those without such history (aIRR = 2.90; 95% CI: 2.43-3.46). Conclusions: Factors associated with time, geography, age, race and ethnicity, sex, and parental history appear to influence the inception of ARE among children and adolescents.
AB - Background: Descriptive epidemiological data on incidence rates (IRs) of asthma with recurrent exacerbations (ARE) are sparse. Objectives: This study hypothesized that IRs for ARE would vary by time, geography, age, and race and ethnicity, irrespective of parental asthma history. Methods: The investigators leveraged data from 17,246 children born after 1990 enrolled in 59 US with 1 Puerto Rican cohort in the Environmental Influences on Child Health Outcomes (ECHO) consortium to estimate IRs for ARE. Results: The overall crude IR for ARE was 6.07 per 1000 person-years (95% CI: 5.63-6.51) and was highest for children aged 2-4 years, for Hispanic Black and non-Hispanic Black children, and for those with a parental history of asthma. ARE IRs were higher for 2- to 4-year-olds in each race and ethnicity category and for both sexes. Multivariable analysis confirmed higher adjusted ARE IRs (aIRRs) for children born 2000-2009 compared with those born 1990-1999 and 2010-2017, 2-4 versus 10-19 years old (aIRR = 15.36; 95% CI: 12.09-19.52), and for males versus females (aIRR = 1.34; 95% CI 1.16-1.55). Black children (non-Hispanic and Hispanic) had higher rates than non-Hispanic White children (aIRR = 2.51; 95% CI 2.10-2.99; and aIRR = 2.04; 95% CI: 1.22-3.39, respectively). Children born in the Midwest, Northeast and South had higher rates than those born in the West (P < .01 for each comparison). Children with a parental history of asthma had rates nearly 3 times higher than those without such history (aIRR = 2.90; 95% CI: 2.43-3.46). Conclusions: Factors associated with time, geography, age, race and ethnicity, sex, and parental history appear to influence the inception of ARE among children and adolescents.
KW - Asthma
KW - environmental and social determinants of asthma
KW - incidence rates
KW - recurrent exacerbations
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U2 - 10.1016/j.jaci.2023.03.016
DO - 10.1016/j.jaci.2023.03.016
M3 - Article
C2 - 36972767
AN - SCOPUS:85156117743
SN - 0091-6749
VL - 152
SP - 84
EP - 93
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 1
ER -