Increased rates of adverse perinatal outcomes in women with gestational diabetes and depression

Claire H. Packer, Rachel A. Pilliod, Louisa R. Chatroux, Aaron B. Caughey, Amy M. Valent

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective: We sought to examine the impact of depression on adverse perinatal outcomes in women with Gestational Diabetes Mellitus (GDM). Methods: We performed a retrospective cohort study comparing the rates of perinatal complications among singleton, nonanomalous births to women with GDM and the diagnosis of depression compared to GDM women without depression between 2007 and 2011 in California. Perinatal outcomes were analyzed using chi-square and multivariable logistic regression to compare frequencies of characteristics and outcomes and to determine the strength of association of depression and adverse perinatal outcomes among women with GDM. Statistical comparisons with a p-value of less than.05 and 95% CI that did not cross the null were considered statistically significant. Results: Among the cohort of 170,572 women with GDM, 2090 (1.22%) were diagnosed with antenatal depression. Women with GDM and depression had significantly higher rates of preeclampsia (adjusted Odds Ratio [aOR] 1.28, 95% CI 1.11–1.49) and gestational hypertension (aOR 1.23, 95% CI 1.05–1.44). Women with GDM and depression also had higher rates of preterm delivery at <37, and <34 weeks gestational age (aOR 1.33, 95% CI 1.18–1.50 and 1.36, 95% CI 1.15–1.61, respectively). Conclusion: Women with GDM and a diagnosis of depression have higher rates of adverse perinatal outcomes than women with GDM alone. Identifying and managing depression among women with GDM has the potential to improve the care and health of this high-risk population.

Original languageEnglish (US)
Pages (from-to)3862-3866
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number23
StatePublished - 2021


  • Gestational diabetes
  • adverse perinatal outcomes
  • antenatal depression
  • preeclampsia
  • preterm birth

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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