TY - JOUR
T1 - Increased Risk of Preeclampsia with Assisted Reproductive Technologies
AU - Kornfield, Molly S.
AU - Gurley, Susan B.
AU - Vrooman, Lisa A.
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/9
Y1 - 2023/9
N2 - Purpose of Review: We summarized recent available data to assess the association between assisted reproductive technology (ART) and risk for preeclampsia. Recent Findings: The majority of clinical studies supporting the association of preeclampsia and ART are retrospective. Published data from both clinical and pre-clinical studies suggest specific ART procedures may contribute to the increased risk, including in vitro embryo handling and development, hormone stimulation, transfer cycle types, and use of donor oocytes/embryos. Potential mechanisms include epigenetic aberrations leading to abnormal placentation, absence of factors secreted by the corpus luteum, and immunologic responses to allogenic gametes. Summary: There is an increased risk of preeclampsia following ART. Treatment plans that favor reduced preeclampsia risk should be considered for ART pregnancies. To make ART pregnancies safer, additional clinical and animal model studies are needed to elucidate the underpinnings of this risk association.
AB - Purpose of Review: We summarized recent available data to assess the association between assisted reproductive technology (ART) and risk for preeclampsia. Recent Findings: The majority of clinical studies supporting the association of preeclampsia and ART are retrospective. Published data from both clinical and pre-clinical studies suggest specific ART procedures may contribute to the increased risk, including in vitro embryo handling and development, hormone stimulation, transfer cycle types, and use of donor oocytes/embryos. Potential mechanisms include epigenetic aberrations leading to abnormal placentation, absence of factors secreted by the corpus luteum, and immunologic responses to allogenic gametes. Summary: There is an increased risk of preeclampsia following ART. Treatment plans that favor reduced preeclampsia risk should be considered for ART pregnancies. To make ART pregnancies safer, additional clinical and animal model studies are needed to elucidate the underpinnings of this risk association.
KW - Assisted reproductive technology
KW - Frozen embryo transfer
KW - Hypertensive disorders of pregnancy
KW - Preeclampsia
KW - Pregnancy complications
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U2 - 10.1007/s11906-023-01250-8
DO - 10.1007/s11906-023-01250-8
M3 - Review article
C2 - 37303020
AN - SCOPUS:85161474579
SN - 1522-6417
VL - 25
SP - 251
EP - 261
JO - Current Hypertension Reports
JF - Current Hypertension Reports
IS - 9
ER -