Induction and reversal of the magnesium deficiency syndrome in inbred mice

J. K. Belknap, J. H. Berg, R. Cocke, A. N. Clancy

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7 Scopus citations


Mice of the DBA 2J and C57BL 6J strains were exposed to a low-magnesium diet and the behavioral manifestations of Mg deficiency were monitored. The DBA mice were markedly more sensitive in terms of symptomatology to magnesium losses than were the C57 mice. Intracranial (0.08 meq/kg) and intraperitoneal (3.0 meq/kg) MgSO4 injections were equally fast (within 2 to 4 h) and effective in eliminating gross tremors and seizures in Mg-deficient mice. However, the total elimination of all symptoms required at least 24 h after very large (4.5 meq/kg × 2) intraperitoneal doses of MgSO4, indicating that more slowly reversing metabolic derangements secondary to Mg deficiency are responsible for the lengthy therapeutic "lag period".

Original languageEnglish (US)
Pages (from-to)506-515
Number of pages10
JournalExperimental Neurology
Issue number2
StatePublished - Nov 1977
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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