Infection of the Retina by Human Immunodeficiency Virus Type I

Roger J. Pomerantz, Daniel R. Kuritzkes, Suzanne M. de la Monte, Teresa R. Rota, Ann S. Baker, Daniel Albert, David H. Bor, Edward L. Feldman, Robert T. Schooley, Martin S. Hirsch

Research output: Contribution to journalArticlepeer-review

182 Scopus citations


HUMAN immunodeficiency virus (HIV) is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).1 2 3 4 HIV penetrates specific cells bearing the CD4 surface antigen5,6 and has been observed in helper T lymphocytes, monocytes, Langerhans' cells, and recently, astrocytes, endothelial cells, oligodendrocytes, and neurons.7 8 9 10 11 HIV-infected cells have been found in the blood, semen, vaginal secretions, breast milk, lymph nodes, brain, spinal cord, and peripheral nerves.7 8 9 10 11 12 13 14 15 16 17 18 19 Many patients with HIV infection have a variety of ocular abnormalities not associated with obvious opportunistic infections; these abnormalities include cotton-wool spots and microvascular changes of the retina.20 21 22 23 24 25 26 27 These observations, together with the established neurotropism of HIV,.

Original languageEnglish (US)
Pages (from-to)1643-1647
Number of pages5
JournalNew England Journal of Medicine
Issue number26
StatePublished - Dec 24 1987
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Infection of the Retina by Human Immunodeficiency Virus Type I'. Together they form a unique fingerprint.

Cite this