Inflammation and pregnancy

John R. Challis, Charles J. Lockwood, Leslie Myatt, Jane E. Norman, Jerome F. Strauss, Felice Petraglia

Research output: Contribution to journalArticlepeer-review

671 Scopus citations


Inflammation is a process by which tissues respond to various insults. It is characterized by upregulation of chemokines, cytokines, and pattern recognition receptors that sense microbes and tissue breakdown products. During pregnancy, the balance of Th1 (cell-mediated immunity) and Th2 (humoral immunity) cytokines is characterized by an initial prevalence of Th2 cytokines, followed by a progressive shift toward Th1 predominance late in gestation, that when is abnormal, may initiate and intensify the cascade of inflammatory cytokine production involved in adverse pregnancy outcomes. Maternal and placental hormones may affect the inflammatory pathway. Hypoxia and the innate immune response are 2 adaptive mechanisms by which organisms respond to perturbation in organ function, playing a major role in spontaneous abortion, intrauterine growth restriction, preeclampsia, and preterm delivery. The interaction between tissue remodeling factors, like matrix metalloproteinases, and vasoactive/hemostatic factors, like prostaglandin and coagulation factors, mediates this adaptive response.

Original languageEnglish (US)
Pages (from-to)206-215
Number of pages10
JournalReproductive Sciences
Issue number2
StatePublished - Feb 2009
Externally publishedYes


  • Cytokines
  • Hormones
  • Inflammation
  • Intrauterine growth restriction
  • Preeclampsia
  • Preterm delivery
  • Prostaglandins
  • Spontaneous abortion

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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