Influence of cadmium on caries and the cariostatic properties of fluoride in rats

T. R. Shearer, J. L. Britton, D. J. Desart, J. R. Johnson

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Cadmium injections during molar tooth development in the rat were strongly caries-promoting in female rats. Cadmium also partially negated the cariostatic effects of fluoridated drinking water in both male and female rats. The mechanism for the caries-promoting properties of cadmium is unknown, but may be related to cadmium uptake into enamel and dentin. Cadmium was taken up into molar enamel and dentin in proportion to the amount of cadmium administered, but cadmium did not influence uptake of fluoride onto erupted enamel. Calcium and ash concentrations in molar enamel were not altered by cadmium administration.

Original languageEnglish (US)
Pages (from-to)176-180
Number of pages5
JournalArchives of Environmental Health
Issue number3
StatePublished - May 1980
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Chemistry
  • General Environmental Science
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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