Inhibin and reproductive aging in women

Michael R. Soules; David E. Battaglia; Nancy A. Klein

doi:10.1016/S0378-5122(98)00074-7

Inhibin and reproductive aging in women

Michael R. Soules, David E. Battaglia, Nancy A. Klein

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The monotropic FSH rise is the sentinel endocrine event that first indicates a woman is approaching the end of her reproductive potential. While a deficiency in inhibin has long been postulated as the immediate cause of the monotropic FSH rise, this has only recently been demonstrated to actually occur. It is our current hypothesis that when the number of preantral follicles in both ovaries drop below a threshold, then there is a subtle decrease in inhibin B which leads to the monotropic FSH rise which, in turn, accelerates follicular depletion and the attainment of the menopause. Copyright (C) 1998 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	193-204
Number of pages	12
Journal	Maturitas
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/S0378-5122(98)00074-7
State	Published - Oct 12 1998

Keywords

Aging
Inhibin
Menopause
Reproductive potential

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Obstetrics and Gynecology

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10.1016/S0378-5122(98)00074-7

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abstract = "The monotropic FSH rise is the sentinel endocrine event that first indicates a woman is approaching the end of her reproductive potential. While a deficiency in inhibin has long been postulated as the immediate cause of the monotropic FSH rise, this has only recently been demonstrated to actually occur. It is our current hypothesis that when the number of preantral follicles in both ovaries drop below a threshold, then there is a subtle decrease in inhibin B which leads to the monotropic FSH rise which, in turn, accelerates follicular depletion and the attainment of the menopause. Copyright (C) 1998 Elsevier Science Ireland Ltd.",

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AB - The monotropic FSH rise is the sentinel endocrine event that first indicates a woman is approaching the end of her reproductive potential. While a deficiency in inhibin has long been postulated as the immediate cause of the monotropic FSH rise, this has only recently been demonstrated to actually occur. It is our current hypothesis that when the number of preantral follicles in both ovaries drop below a threshold, then there is a subtle decrease in inhibin B which leads to the monotropic FSH rise which, in turn, accelerates follicular depletion and the attainment of the menopause. Copyright (C) 1998 Elsevier Science Ireland Ltd.

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KW - Menopause

KW - Reproductive potential

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Inhibin and reproductive aging in women

Abstract

Keywords

ASJC Scopus subject areas

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