Inhibition of the renin-angiotensin system: Is more better?

Sharon Anderson; Radko Komers

doi:10.1038/ki.2008.556

Inhibition of the renin-angiotensin system: Is more better?

Sharon Anderson, Radko Komers

Research output: Contribution to journal › Comment/debate › peer-review

11 Scopus citations

Abstract

Inhibitors of the renin-angiotensin-aldosterone system (RAS) exert beneficial effects in diabetic nephropathy, but the possibility of regression of existing renal lesions remains to be investigated. Teles et al. tested the effects of the RAS inhibitor losartan in rats starting 10 months after induction of diabetes, when glomerular lesions were already present. They linked the reductions of proteinuria with regression of mesangial expansion. More advanced lesions were not affected. There were no dose-response renal effects of losartan.

Original language	English (US)
Pages (from-to)	12-14
Number of pages	3
Journal	Kidney International
Volume	75
Issue number	1
DOIs	https://doi.org/10.1038/ki.2008.556
State	Published - Jan 2009

ASJC Scopus subject areas

Nephrology

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10.1038/ki.2008.556

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title = "Inhibition of the renin-angiotensin system: Is more better?",

abstract = "Inhibitors of the renin-angiotensin-aldosterone system (RAS) exert beneficial effects in diabetic nephropathy, but the possibility of regression of existing renal lesions remains to be investigated. Teles et al. tested the effects of the RAS inhibitor losartan in rats starting 10 months after induction of diabetes, when glomerular lesions were already present. They linked the reductions of proteinuria with regression of mesangial expansion. More advanced lesions were not affected. There were no dose-response renal effects of losartan.",

author = "Sharon Anderson and Radko Komers",

note = "Funding Information: Studies in the authors' laboratory were supported, in part, by grants from the United States National Institutes of Health (DK63231 to S.A.) and the Juvenile Diabetes Research Foundation (1-2008-314 to R.K.).",

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AU - Komers, Radko

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N2 - Inhibitors of the renin-angiotensin-aldosterone system (RAS) exert beneficial effects in diabetic nephropathy, but the possibility of regression of existing renal lesions remains to be investigated. Teles et al. tested the effects of the RAS inhibitor losartan in rats starting 10 months after induction of diabetes, when glomerular lesions were already present. They linked the reductions of proteinuria with regression of mesangial expansion. More advanced lesions were not affected. There were no dose-response renal effects of losartan.

AB - Inhibitors of the renin-angiotensin-aldosterone system (RAS) exert beneficial effects in diabetic nephropathy, but the possibility of regression of existing renal lesions remains to be investigated. Teles et al. tested the effects of the RAS inhibitor losartan in rats starting 10 months after induction of diabetes, when glomerular lesions were already present. They linked the reductions of proteinuria with regression of mesangial expansion. More advanced lesions were not affected. There were no dose-response renal effects of losartan.

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Inhibition of the renin-angiotensin system: Is more better?

Abstract

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