Inhibition of the renin-angiotensin system: Is more better?

Sharon Anderson, Radko Komers

Research output: Contribution to journalComment/debatepeer-review

11 Scopus citations


Inhibitors of the renin-angiotensin-aldosterone system (RAS) exert beneficial effects in diabetic nephropathy, but the possibility of regression of existing renal lesions remains to be investigated. Teles et al. tested the effects of the RAS inhibitor losartan in rats starting 10 months after induction of diabetes, when glomerular lesions were already present. They linked the reductions of proteinuria with regression of mesangial expansion. More advanced lesions were not affected. There were no dose-response renal effects of losartan.

Original languageEnglish (US)
Pages (from-to)12-14
Number of pages3
JournalKidney International
Issue number1
StatePublished - Jan 2009
Externally publishedYes

ASJC Scopus subject areas

  • Nephrology


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