Insight and prefrontal cortex in first-episode Schizophrenia

Mujeeb U. Shad, Sri Muddasani, Konasale Prasad, John A. Sweeney, Matcheri S. Keshavan

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


Few studies have investigated the neurobiological basis of impaired insight in antipsychotic-naive schizophrenia. However, the relationship between insight and specific prefrontally mediated cognitive functions suggests that insight deficits may be an expression of prefrontal cortical dysfunction. This study was designed to examine the relationship among insight, neurocognition, and dorsolateral prefrontal cortex (DLPFC) volumes in first-episode antipsychotic-naive schizophrenia subjects. DLPFC volumes were compared between 35 first-episode schizophrenia subjects with good (n = 17) and poor insight (n = 18). Morphometric measurements were based on MRI scans by trained raters blind to clinical information. First-episode schizophrenia subjects with poor insight showed decreased right DLPFC volumes relative to those with good insight. In addition, those with poor insight had higher levels of perseverative errors (PEs) on the Wisconsin Card Sort Test (WCST). No differences in other neuropsychological measures were found between the good and poor insight groups. Similarly, no differences were found between schizophrenia subjects with good versus poor insight on any of the psychopathological measures employed in this study. These findings suggest that poor insight in schizophrenia may be a function of specific prefrontally mediated neurocognitive deficits rather than a global impairment in neuropsychological functioning or different profiles of psychopathology.

Original languageEnglish (US)
Pages (from-to)1315-1320
Number of pages6
Issue number3
StatePublished - Jul 2004
Externally publishedYes


  • First-episode schizophrenia
  • Insight
  • Prefrontal cortex

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


Dive into the research topics of 'Insight and prefrontal cortex in first-episode Schizophrenia'. Together they form a unique fingerprint.

Cite this