TY - JOUR
T1 - Insights into the mechanism and pharmacology of neurotransmitter sodium symporters
AU - Navratna, Vikas
AU - Gouaux, Eric
N1 - Funding Information:
We thank J. Coleman, F. Jalali-Yazdi, and D. Yang for discussion and valuable inputs on the manuscript, L. Vaskalis for assistance with figures, and H. Owen for help with manuscript preparation. This work was supported by the National Institute of Mental Health of the NIH under award number R37MH070039 . E.G. is an investigator with the Howard Hughes Medical Institute.
Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/2
Y1 - 2019/2
N2 - Neurotransmitter sodium symporters (NSS) belong to the SLC6 family of solute carriers and play an essential role in neurotransmitter homeostasis throughout the body. In the past decade, structural studies employing bacterial orthologs of NSSs have provided insight into the mechanism of neurotransmitter transport. While the overall architecture of SLC6 transporters is conserved among species, in comparison to the bacterial homologs, the eukaryotic SLC6 family members harbor differences in amino acid sequence and molecular structure, which underpins their functional and pharmacological diversity, as well as their ligand specificity. Here, we review the structures and mechanisms of eukaryotic NSSs, focusing on the molecular basis for ligand recognition and on transport mechanism.
AB - Neurotransmitter sodium symporters (NSS) belong to the SLC6 family of solute carriers and play an essential role in neurotransmitter homeostasis throughout the body. In the past decade, structural studies employing bacterial orthologs of NSSs have provided insight into the mechanism of neurotransmitter transport. While the overall architecture of SLC6 transporters is conserved among species, in comparison to the bacterial homologs, the eukaryotic SLC6 family members harbor differences in amino acid sequence and molecular structure, which underpins their functional and pharmacological diversity, as well as their ligand specificity. Here, we review the structures and mechanisms of eukaryotic NSSs, focusing on the molecular basis for ligand recognition and on transport mechanism.
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U2 - 10.1016/j.sbi.2019.03.011
DO - 10.1016/j.sbi.2019.03.011
M3 - Review article
C2 - 30921707
AN - SCOPUS:85063204351
SN - 0959-440X
VL - 54
SP - 161
EP - 170
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
ER -