TY - JOUR
T1 - Integrated backscatter and digital acquisition during myocardial contrast echocardiography
T2 - Is there an advantage over conventional echocardiography for intracoronary injections?
AU - Ismail, Suad
AU - Jayaweera, Ananda R.
AU - Skyba, Danny M.
AU - Sklenar, Jiri
AU - Goodman, Norman C.
AU - Kaul, Sanjiv
N1 - Funding Information:
Myocardialc ontrast echocardiography (MCE) is a technique that uses the intravascular injection of microbubbles of air during simultaneously performed From the Cardiovascular Division, University of Virginia School of Medicine. Supported in part by grants from the National Institutes of Health, Bethesda, Maryland (R01-HL48890), the Virginia Affiliateo f the American Heart Association, Glen Allen, Virginia, and Molecular Biosystems, Inc., San Diego, California, and an equipment grant from Hewlett-Packard Co., Andover, Massachusetts. aRecipient of a fellowship training grant from the Virginia affiliate of the American Heart Association. 6Established Investigator of the National Center of the American Heart Association, Dallas, Texas. Reprint requests: Sanjiv Kaul, MD, CardiovascularD ivision, Box 158, Medical Center, University of Virginia, Charlottesville,V A 22908. Copyright 9 1995 by the American Societyo f Echocardiography. 0894-7317/95 $3.00 + 0 27/1/62106 two-dimensional (2D) echocardiography to characterize myocardial perfusion. 1 During conventional 2D echocardiography, data undergo various nonlinear transformations before the final image is formed. In clinical practice the image is then usually stored on videotape with a potential loss of dynamic range.
PY - 1995
Y1 - 1995
N2 - This study was designed to answer the question of whether, despite their theoretic superiority, integrated backscatter imaging (IBS) and digital data acquisition (DA) offer any advantage over conventional echocardiography (CE) during quantitative myocardial contrast echocardiography. In vitro experiments were performed (1) to determine the microbubble concentration versus videointensity relationships for CE and IBS and (2) to define the relationship between flow through and microbubble transit rates for CE and IBS. These data were stored on videotape. In vivo experiments were performed whereby microbubbles were injected into the left anterior descending artery at different flow rates in 14 dogs and IBS and CE data were stored both in difital format and on videotape. Although the level of compression did not affect the microbubble concentration versus videointensity plots during IBS compared with CE, in practical terms the mean transit rate, peak intensity, and area under the curve were not affected by the level of compression for both forms of imaging as long as the postprocessing used for CE imaging was linear and the microbubble dose was small. In addition, although DA resulted in higher peak intensity and area under the curve compared with storage on videotape because of its broader dynamic range, the correlation between these measurements was excellent with both forms of image storage. We conclude that, although differences exist between CE and IBS and between DA and analog acquisition, these differences do not significantly affect the derivation of parameters from time-intensity plots during myocardial contrast echocardiography when contrast material is injected into a coronary artery.
AB - This study was designed to answer the question of whether, despite their theoretic superiority, integrated backscatter imaging (IBS) and digital data acquisition (DA) offer any advantage over conventional echocardiography (CE) during quantitative myocardial contrast echocardiography. In vitro experiments were performed (1) to determine the microbubble concentration versus videointensity relationships for CE and IBS and (2) to define the relationship between flow through and microbubble transit rates for CE and IBS. These data were stored on videotape. In vivo experiments were performed whereby microbubbles were injected into the left anterior descending artery at different flow rates in 14 dogs and IBS and CE data were stored both in difital format and on videotape. Although the level of compression did not affect the microbubble concentration versus videointensity plots during IBS compared with CE, in practical terms the mean transit rate, peak intensity, and area under the curve were not affected by the level of compression for both forms of imaging as long as the postprocessing used for CE imaging was linear and the microbubble dose was small. In addition, although DA resulted in higher peak intensity and area under the curve compared with storage on videotape because of its broader dynamic range, the correlation between these measurements was excellent with both forms of image storage. We conclude that, although differences exist between CE and IBS and between DA and analog acquisition, these differences do not significantly affect the derivation of parameters from time-intensity plots during myocardial contrast echocardiography when contrast material is injected into a coronary artery.
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U2 - 10.1016/S0894-7317(05)80332-3
DO - 10.1016/S0894-7317(05)80332-3
M3 - Article
C2 - 7546781
AN - SCOPUS:0029337248
SN - 0894-7317
VL - 8
SP - 453
EP - 464
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 4
ER -