Integrating phenotype ontologies across multiple species

Christopher J. Mungall, Georgios V. Gkoutos, Cynthia L. Smith, Melissa A. Haendel, Suzanna E. Lewis, Michael Ashburner

Research output: Contribution to journalArticlepeer-review

226 Scopus citations


Phenotype ontologies are typically constructed to serve the needs of a particular community, such as annotation of genotype-phenotype associations in mouse or human. Here we demonstrate how these ontologies can be improved through assignment of logical definitions using a core ontology of phenotypic qualities and multiple additional ontologies from the Open Biological Ontologies library. We also show how these logical definitions can be used for data integration when combined with a unified multi-species anatomy ontology.

Original languageEnglish (US)
Article numberr2
JournalGenome biology
Issue number1
StatePublished - Jan 8 2010
Externally publishedYes

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology


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