Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1

Medicine & Life Sciences

• DNA-(Apurinic or Apyrimidinic Site) Lyase 100%
• DNA Cleavage 89%
• Mitoxantrone 86%
• DNA 34%
• tetrahydrofuran 29%
• Aldehydes 21%
• Phosphates 10%
• Sugar Phosphates 9%
• Polynucleotide 5'-Hydroxyl-Kinase 9%
• Schiff Bases 9%
• anthracene 8%
• Anthraquinones 8%
• Type II DNA Topoisomerase 7%
• Hydrogen Bonding 7%
• Double-Stranded DNA Breaks 6%
• Phosphoric Monoester Hydrolases 6%
• DNA Repair 5%
• Inhibitory Concentration 50 5%
• Hot Temperature 4%
• Poisons 4%

Chemical Compounds

• Mitoxantrone 98%
• Cleavage 45%
• Phosphate(3-) 17%
• Aldehyde 13%
• DNA Structure 7%
• Poison 7%
• Polynucleotide 7%
• Schiff Base 5%
• Additive 4%
• Hydrogen 3%
• Molecule 2%