Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

Jo Ann L. Yee; Kamm Prongay; Brodie Miles; Jeremy Smedley; Scott G. Hansen; Michael K. Axthelm; Amir Ardeshir; Koen K.A. Van Rompay; Gregory Timmel; Jeffrey A. Roberts

doi:10.1111/jmp.12420

Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

Jo Ann L. Yee, Kamm Prongay, Brodie Miles, Jeremy Smedley, Scott G. Hansen, Michael K. Axthelm, Amir Ardeshir, Koen K.A. Van Rompay, Gregory Timmel, Jeffrey A. Roberts

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.

Original language	English (US)
Pages (from-to)	260-263
Number of pages	4
Journal	Journal of medical primatology
Volume	48
Issue number	4
DOIs	https://doi.org/10.1111/jmp.12420
State	Published - Aug 2019

Keywords

cell-mediated immune response (CMI)
interferon-gamma release assay (IGRA)
purified protein derivative—tuberculin (PPD)

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

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10.1111/jmp.12420

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Yee, J. A. L., Prongay, K., Miles, B., Smedley, J., Hansen, S. G., Axthelm, M. K., Ardeshir, A., Van Rompay, K. K. A., Timmel, G., & Roberts, J. A. (2019). Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates. Journal of medical primatology, 48(4), 260-263. https://doi.org/10.1111/jmp.12420

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abstract = "We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.",

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year = "2019",

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language = "English (US)",

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AU - Miles, Brodie

AU - Smedley, Jeremy

AU - Hansen, Scott G.

AU - Axthelm, Michael K.

AU - Ardeshir, Amir

AU - Van Rompay, Koen K.A.

AU - Timmel, Gregory

AU - Roberts, Jeffrey A.

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Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

Abstract

Keywords

ASJC Scopus subject areas

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