Investigating the Impact of Temporal Labeling of Emergency Department Visits for COVID-19: Comparing Healthcare Disparities Analyses Using Comprehensive, Single-Site Data with National COVID Cohort Collaborative (N3C) Data

Madeleine Jones, Aubrey Winger, Christian Wernz, Jonathan Michel, Sihang Jiang, Andrea Zhou, Ebony Jade Hilton, Mikhail Zemmel, Saurav Sengupta, Kierah Barnes, Johanna Loomba, Donald E. Brown, Adam B. Wilcox, Adam M. Lee, Alexis Graves, Alfred Anzalone, Amin Manna, Amit Saha, Amy Olex, Andrew E. WilliamsAndrew Southerland, Andrew T. Girvin, Anita Walden, Anjali A. Sharathkumar, Benjamin Amor, Benjamin Bates, Brian Hendricks, Brijesh Patel, Caleb Alexander, Carolyn Bramante, Cavin Ward-Caviness, Charisse Madlock-Brown, Christine Suver, Christopher Chute, Christopher Dillon, Chunlei Wu, Clare Schmitt, Cliff Takemoto, Dan Housman, Davera Gabriel, David A. Eichmann, Diego Mazzotti, Eilis Boudreau, Elaine Hill, Elizabeth Zampino, Emily Carlson Marti, Emily R. Pfaff, Evan French, Farrukh M. Koraishy, Federico Mariona, Fred Prior, George Sokos, Greg Martin, Harold Lehmann, Heidi Spratt, Hemalkumar Mehta, Hongfang Liu, Hythem Sidky, J. W. Awori Hayanga, Jami Pincavitch, Jaylyn Clark, Jeremy Richard Harper, Jessica Islam, Jin Ge, Joel Gagnier, Joel H. Saltz, John Buse, Jomol Mathew, Joni L. Rutter, Julie A. McMurry, Justin Guinney, Justin Starren, Karen Crowley, Katie Rebecca Bradwell, Kellie M. Walters, Ken Wilkins, Kenneth R. Gersing, Kenrick Dwain Cato, Kimberly Murray, Kristin Kostka, Lavance Northington, Lee Allan Pyles, Leonie Misquitta, Lesley Cottrell, Lili Portilla, Mariam Deacy, Mark M. Bissell, Marshall Clark, Mary Emmett, Mary Morrison Saltz, Matvey B. Palchuk, Melissa A. Haendel, Meredith Adams, Meredith Temple-O'Connor, Michael G. Kurilla, Michele Morris, Nabeel Qureshi, Nasia Safdar, Nicole Garbarini, Noha Sharafeldin, Ofer Sadan, Patricia A. Francis, Penny Wung Burgoon, Peter Robinson, Philip R.O. Payne, Rafael Fuentes, Randeep Jawa, Rebecca Erwin-Cohen, Rena Patel, Richard A. Moffitt, Richard L. Zhu, Rishi Kamaleswaran, Robert Hurley, Robert T. Miller, Saiju Pyarajan, Sam G. Michael, Samuel Bozzette, Sandeep Mallipattu, Satyanarayana Vedula, Scott Chapman, Shawn T. O'Neil, Soko Setoguchi, Stephanie S. Hong, Steve Johnson, Tellen D. Bennett, Tiffany Callahan, Umit Topaloglu, Usman Sheikh, Valery Gordon, Vignesh Subbian, Warren A. Kibbe, Wenndy Hernandez, Will Beasley, Will Cooper, William Hillegass, Xiaohan Tanner Zhang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

National COVID Cohort Collaborative (N3C) enclave provides health researchers with a rich dataset from 76 contributing clinical sites. However, the harmonized data lacks certain details available in sites' local electronic health records (EHRs), such as the principal diagnosis code for reported emergency department (ED) and inpatient (IP) visits. This means a principal diagnosis of COVID-19 can only be inferred by applying a time relationship between the visit dates and the record of infection and diagnosis. The purpose of this study is to perform a single-site sensitivity analysis modeled after an N3C study examining potential race-ethnicity based bias in hospitalization decisions during COVID-19 related ED visits. The analytic pipeline was first run in N3C, then reproduced locally with N3C data fields from a single-site, and finally run a third time using the additional principal diagnosis data. We find the effects of patient comorbidities and race-ethnicity groups on direct IP admittance to be consistent among the three cohorts with varying levels of statistical significance due to different sample sizes.

Original languageEnglish (US)
Title of host publication2023 Systems and Information Engineering Design Symposium, SIEDS 2023
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages297-302
Number of pages6
ISBN (Electronic)9798350300642
DOIs
StatePublished - 2023
Event2023 Systems and Information Engineering Design Symposium, SIEDS 2023 - Charlottesville, United States
Duration: Apr 27 2023Apr 28 2023

Publication series

Name2023 Systems and Information Engineering Design Symposium, SIEDS 2023

Conference

Conference2023 Systems and Information Engineering Design Symposium, SIEDS 2023
Country/TerritoryUnited States
CityCharlottesville
Period4/27/234/28/23

ASJC Scopus subject areas

  • Computer Science Applications
  • Hardware and Architecture
  • Information Systems
  • Decision Sciences (miscellaneous)
  • Information Systems and Management
  • Control and Systems Engineering

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