TY - JOUR
T1 - Investigation of ethanol-induced impairment of spatial memory in γ2 heterozygous knockout mice
AU - Berry, Raymond B.
AU - Chandra, Dev
AU - Diaz-Granados, Jaime L.
AU - Homanics, Gregg E.
AU - Matthews, Douglas B.
N1 - Funding Information:
The authors would like to recognize and thank Carolyn Ferguson for her expert technical assistance, upon which this research depended. Supported by grants AA014588, AA013509 (DBM), DE14184 (DC) and AA10422 (GEH).
PY - 2009/5/15
Y1 - 2009/5/15
N2 - GABAA receptors, the major inhibitory receptors in the mammalian central nervous system, are affected by a number of drug compounds, including ethanol. The pharmacological effects of certain drugs have been shown to be dependent upon specific GABAA receptor subunits. Because benzodiazepines and ethanol have similar effect signatures, it has been hypothesized that these drugs share the γ2-containing GABAA receptors as a mechanism of action. To probe the involvement of the γ2 subunit in ethanol's actions, spatial memory for the Morris water maze task was tested in γ2 heterozygous knockout mice and wild type littermate controls following ethanol administration at the following doses: 0.0, 1.25, 1.75, and 2.25 g/kg. While baseline learning and memory were unaffected by reduction of γ2 containing GABAA receptors, ethanol dose-dependently impaired spatial memory equally in γ2 heterozygous knockouts and wild type littermate controls.
AB - GABAA receptors, the major inhibitory receptors in the mammalian central nervous system, are affected by a number of drug compounds, including ethanol. The pharmacological effects of certain drugs have been shown to be dependent upon specific GABAA receptor subunits. Because benzodiazepines and ethanol have similar effect signatures, it has been hypothesized that these drugs share the γ2-containing GABAA receptors as a mechanism of action. To probe the involvement of the γ2 subunit in ethanol's actions, spatial memory for the Morris water maze task was tested in γ2 heterozygous knockout mice and wild type littermate controls following ethanol administration at the following doses: 0.0, 1.25, 1.75, and 2.25 g/kg. While baseline learning and memory were unaffected by reduction of γ2 containing GABAA receptors, ethanol dose-dependently impaired spatial memory equally in γ2 heterozygous knockouts and wild type littermate controls.
KW - Ethanol
KW - GABA receptor knockout
KW - Morris water maze
KW - Spatial memory
KW - γ2 subunit
UR - http://www.scopus.com/inward/record.url?scp=63449129969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63449129969&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2009.03.046
DO - 10.1016/j.neulet.2009.03.046
M3 - Article
C2 - 19368851
AN - SCOPUS:63449129969
SN - 0304-3940
VL - 455
SP - 84
EP - 87
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -