Involvement of insula and cingulate cortices in control and suppression of natural urges

Alicja Lerner; Anto Bagic; Takashi Hanakawa; Eilis A. Boudreau; Fernando Pagan; Zoltan Mari; William Bara-Jimenez; Murat Aksu; Susumu Sato; Dennis L. Murphy; Mark Hallett

doi:10.1093/cercor/bhn074

Involvement of insula and cingulate cortices in control and suppression of natural urges

Alicja Lerner, Anto Bagic, Takashi Hanakawa, Eilis A. Boudreau, Fernando Pagan, Zoltan Mari, William Bara-Jimenez, Murat Aksu, Susumu Sato, Dennis L. Murphy, Mark Hallett

Neurology

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

The physiology of control and suppression of natural urges is not well understood. We used [¹⁵O]H₂O positron-emission tomography imaging to identify neural circuits involved in suppression of spontaneous blinking as a model of normal urges. Suppression of blinking was associated with prominent activation of bilateral insular-claustrum regions, right more than left; activation was also found in bilateral anterior cingulate cortex (ACC), supplementary motor areas, and the face area of the primary motor cortex bilaterally. These results suggest a central role for the insula possibly together with ACC in suppression of blinking.

Original language	English (US)
Pages (from-to)	218-223
Number of pages	6
Journal	Cerebral Cortex
Volume	19
Issue number	1
DOIs	https://doi.org/10.1093/cercor/bhn074
State	Published - Jan 2009

Keywords

Blinking
Insula
PET
Suppression
Urges
Visceral homunculus

ASJC Scopus subject areas

Cognitive Neuroscience
Cellular and Molecular Neuroscience

Access to Document

10.1093/cercor/bhn074

Cite this

@article{5bfb0b7588024418a5ac4146f01c8d90,

title = "Involvement of insula and cingulate cortices in control and suppression of natural urges",

abstract = "The physiology of control and suppression of natural urges is not well understood. We used [15O]H2O positron-emission tomography imaging to identify neural circuits involved in suppression of spontaneous blinking as a model of normal urges. Suppression of blinking was associated with prominent activation of bilateral insular-claustrum regions, right more than left; activation was also found in bilateral anterior cingulate cortex (ACC), supplementary motor areas, and the face area of the primary motor cortex bilaterally. These results suggest a central role for the insula possibly together with ACC in suppression of blinking.",

keywords = "Blinking, Insula, PET, Suppression, Urges, Visceral homunculus",

author = "Alicja Lerner and Anto Bagic and Takashi Hanakawa and Boudreau, {Eilis A.} and Fernando Pagan and Zoltan Mari and William Bara-Jimenez and Murat Aksu and Susumu Sato and Murphy, {Dennis L.} and Mark Hallett",

year = "2009",

month = jan,

doi = "10.1093/cercor/bhn074",

language = "English (US)",

volume = "19",

pages = "218--223",

journal = "Cerebral Cortex",

issn = "1047-3211",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Involvement of insula and cingulate cortices in control and suppression of natural urges

AU - Lerner, Alicja

AU - Bagic, Anto

AU - Hanakawa, Takashi

AU - Boudreau, Eilis A.

AU - Pagan, Fernando

AU - Mari, Zoltan

AU - Bara-Jimenez, William

AU - Aksu, Murat

AU - Sato, Susumu

AU - Murphy, Dennis L.

AU - Hallett, Mark

PY - 2009/1

Y1 - 2009/1

N2 - The physiology of control and suppression of natural urges is not well understood. We used [15O]H2O positron-emission tomography imaging to identify neural circuits involved in suppression of spontaneous blinking as a model of normal urges. Suppression of blinking was associated with prominent activation of bilateral insular-claustrum regions, right more than left; activation was also found in bilateral anterior cingulate cortex (ACC), supplementary motor areas, and the face area of the primary motor cortex bilaterally. These results suggest a central role for the insula possibly together with ACC in suppression of blinking.

AB - The physiology of control and suppression of natural urges is not well understood. We used [15O]H2O positron-emission tomography imaging to identify neural circuits involved in suppression of spontaneous blinking as a model of normal urges. Suppression of blinking was associated with prominent activation of bilateral insular-claustrum regions, right more than left; activation was also found in bilateral anterior cingulate cortex (ACC), supplementary motor areas, and the face area of the primary motor cortex bilaterally. These results suggest a central role for the insula possibly together with ACC in suppression of blinking.

KW - Blinking

KW - Insula

KW - PET

KW - Suppression

KW - Urges

KW - Visceral homunculus

UR - http://www.scopus.com/inward/record.url?scp=57749184131&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57749184131&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhn074

DO - 10.1093/cercor/bhn074

M3 - Article

C2 - 18469316

AN - SCOPUS:57749184131

SN - 1047-3211

VL - 19

SP - 218

EP - 223

JO - Cerebral Cortex

JF - Cerebral Cortex

IS - 1

ER -

Involvement of insula and cingulate cortices in control and suppression of natural urges

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this