Ion conductances affected by 5-HT receptor subtypes in mammalian neurons

Daniel H. Bobker; John T. Williams

doi:10.1016/0166-2236(90)90042-9

Ion conductances affected by 5-HT receptor subtypes in mammalian neurons

Daniel H. Bobker, John T. Williams

Vollum Institute

Research output: Contribution to journal › Review article › peer-review

105 Scopus citations

Abstract

5-Hydroxytryptamine (5-HT) has both excitatory and inhibitory actions in the CNS and PNS. The development of new 5-HT ligands has led to the expansion of 5-HT receptor subtypes into three categories: 5-HT₁, 5-HT₂ and 5-HT₃ (Ref. 1). Each category has further subdivisions. The literature concerning the biochemical basis of this division has been reviewed recently². While this approach has elucidated many of the pharmacological properties of 5-HT receptors, it has not addressed the question of how 5-HT modulates cell excitability. Physiological studies have confirmed the existence of a multiplicity of 5-HT receptors that act through a variety of ionic mechanisms. The purpose of this review is to summarize what is known of the ionic mechanisms associated with the activation of identified mammalian 5-HT receptor subtypes, as well as some effects of 5-HT where the receptor could not be defined.

Original language	English (US)
Pages (from-to)	169-173
Number of pages	5
Journal	Trends in Neurosciences
Volume	13
Issue number	5
DOIs	https://doi.org/10.1016/0166-2236(90)90042-9
State	Published - May 1990

ASJC Scopus subject areas

General Neuroscience

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10.1016/0166-2236(90)90042-9

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title = "Ion conductances affected by 5-HT receptor subtypes in mammalian neurons",

abstract = "5-Hydroxytryptamine (5-HT) has both excitatory and inhibitory actions in the CNS and PNS. The development of new 5-HT ligands has led to the expansion of 5-HT receptor subtypes into three categories: 5-HT1, 5-HT2 and 5-HT3 (Ref. 1). Each category has further subdivisions. The literature concerning the biochemical basis of this division has been reviewed recently2. While this approach has elucidated many of the pharmacological properties of 5-HT receptors, it has not addressed the question of how 5-HT modulates cell excitability. Physiological studies have confirmed the existence of a multiplicity of 5-HT receptors that act through a variety of ionic mechanisms. The purpose of this review is to summarize what is known of the ionic mechanisms associated with the activation of identified mammalian 5-HT receptor subtypes, as well as some effects of 5-HT where the receptor could not be defined.",

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AU - Williams, John T.

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N2 - 5-Hydroxytryptamine (5-HT) has both excitatory and inhibitory actions in the CNS and PNS. The development of new 5-HT ligands has led to the expansion of 5-HT receptor subtypes into three categories: 5-HT1, 5-HT2 and 5-HT3 (Ref. 1). Each category has further subdivisions. The literature concerning the biochemical basis of this division has been reviewed recently2. While this approach has elucidated many of the pharmacological properties of 5-HT receptors, it has not addressed the question of how 5-HT modulates cell excitability. Physiological studies have confirmed the existence of a multiplicity of 5-HT receptors that act through a variety of ionic mechanisms. The purpose of this review is to summarize what is known of the ionic mechanisms associated with the activation of identified mammalian 5-HT receptor subtypes, as well as some effects of 5-HT where the receptor could not be defined.

AB - 5-Hydroxytryptamine (5-HT) has both excitatory and inhibitory actions in the CNS and PNS. The development of new 5-HT ligands has led to the expansion of 5-HT receptor subtypes into three categories: 5-HT1, 5-HT2 and 5-HT3 (Ref. 1). Each category has further subdivisions. The literature concerning the biochemical basis of this division has been reviewed recently2. While this approach has elucidated many of the pharmacological properties of 5-HT receptors, it has not addressed the question of how 5-HT modulates cell excitability. Physiological studies have confirmed the existence of a multiplicity of 5-HT receptors that act through a variety of ionic mechanisms. The purpose of this review is to summarize what is known of the ionic mechanisms associated with the activation of identified mammalian 5-HT receptor subtypes, as well as some effects of 5-HT where the receptor could not be defined.

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Ion conductances affected by 5-HT receptor subtypes in mammalian neurons

Abstract

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