TY - JOUR
T1 - Isolation, sequencing, and mapping of the human homologue of the yeast transcription factor, SPT5
AU - Chiang, Pei Wen
AU - Fogel, Eric
AU - Jackson, Cynthia L.
AU - Lieuallen, Kim
AU - Lennon, Greg
AU - Qu, Xuan
AU - Wang, Su Qing
AU - Kurnit, David M.
N1 - Funding Information:
We thank K. Walsh and R. M. Preparata for technical assistance. Support was from NIH Grant 1 R01 HG00923, DOE Grant DE-FG02-91ER61136, and by the Howard Hughes Medical Institute. D.M.K. is an Investigator at the Howard Hughes Medical Institute. Work by G.L. and K.L. was supported by DOE Contract W-7405-Eng-48.
PY - 1996/12/15
Y1 - 1996/12/15
N2 - We isolated the human homologue, SUPT5H, of the yeast transcription factor, SPT5. The human homologue is 1088 aa long compared to 1063 aa for the yeast gene. SUPT5H maps to 19q13, near the ryanodine receptor. Like its family member, SUPT6H, and like yeast SPT5, SUPT5H has a very acidic 5' domain. Like its family member, SUPT6H, but unlike yeast SPT5 or SPT6, SUPT5H has seven MAP kinase sites at its 5' end. In addition, SUPT5H lacks the novel 6-amino-acid repeat (consensus is S-T/A-W-G-G-A/Q) at the C-terminus of yeast SPT5. This argues that while there is functional similarity between SPT5 and SUPT5H, the molecules differ in the signals to which they respond.
AB - We isolated the human homologue, SUPT5H, of the yeast transcription factor, SPT5. The human homologue is 1088 aa long compared to 1063 aa for the yeast gene. SUPT5H maps to 19q13, near the ryanodine receptor. Like its family member, SUPT6H, and like yeast SPT5, SUPT5H has a very acidic 5' domain. Like its family member, SUPT6H, but unlike yeast SPT5 or SPT6, SUPT5H has seven MAP kinase sites at its 5' end. In addition, SUPT5H lacks the novel 6-amino-acid repeat (consensus is S-T/A-W-G-G-A/Q) at the C-terminus of yeast SPT5. This argues that while there is functional similarity between SPT5 and SUPT5H, the molecules differ in the signals to which they respond.
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U2 - 10.1006/geno.1996.0646
DO - 10.1006/geno.1996.0646
M3 - Article
C2 - 8975720
AN - SCOPUS:0030589591
SN - 0888-7543
VL - 38
SP - 421
EP - 424
JO - Genomics
JF - Genomics
IS - 3
ER -