TY - GEN
T1 - Iterative function separation for gene regulatory function identification
AU - Bhushan, Palak
AU - Chang, Young Hwan
AU - Tomlin, Claire J.
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2015/2/8
Y1 - 2015/2/8
N2 - In this work, we pose the problem of gene regulatory function identification using a new general framework based on function separation. We prove the uniqueness of the solution within this framework in an almost always sense. Additionally, we develop an iterative scheme, called iterative function separation (IFS), which is guaranteed to converge to a solution. Both these results together guarantee the computation of the unique solution. We also develop theoretical limits on the number of gene expression level measurements (time samples) sufficient to uniquely reconstruct the network. The proposed method (IFS) is validated using synthetic networks both within and outside of the modeling domain of the new framework.
AB - In this work, we pose the problem of gene regulatory function identification using a new general framework based on function separation. We prove the uniqueness of the solution within this framework in an almost always sense. Additionally, we develop an iterative scheme, called iterative function separation (IFS), which is guaranteed to converge to a solution. Both these results together guarantee the computation of the unique solution. We also develop theoretical limits on the number of gene expression level measurements (time samples) sufficient to uniquely reconstruct the network. The proposed method (IFS) is validated using synthetic networks both within and outside of the modeling domain of the new framework.
UR - http://www.scopus.com/inward/record.url?scp=84962020043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962020043&partnerID=8YFLogxK
U2 - 10.1109/CDC.2015.7402098
DO - 10.1109/CDC.2015.7402098
M3 - Conference contribution
AN - SCOPUS:84962020043
T3 - Proceedings of the IEEE Conference on Decision and Control
SP - 133
EP - 138
BT - 54rd IEEE Conference on Decision and Control,CDC 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 54th IEEE Conference on Decision and Control, CDC 2015
Y2 - 15 December 2015 through 18 December 2015
ER -