Karyotypic analysis of a near diploid established mouse cell line

R. A. Farber; R. M. Liskay

doi:10.1159/000130288

Karyotypic analysis of a near diploid established mouse cell line

R. A. Farber, R. M. Liskay

Molecular and Medical Genetics

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A near diploid mouse cell line has been produced from C57BL/6J X AKR/J F₁ hybrid embryonic cells by spontaneous transformation. The modal chromosome number of this line is 41 (2n = 40), with low numerical and structural variation relative to other mouse lines which have been reported. Giemsa banded karyotypes on a number of clones and subclones from this line have been analyzed. The most modal karyotypes deviate very little from that of a normal diploid female. Most of the cells have two X chromosomes, one of which is unlabeled early in the S phase.

Original language	English (US)
Pages (from-to)	384-396
Number of pages	13
Journal	Cytogenetics and Cell Genetics
Volume	13
Issue number	4
DOIs	https://doi.org/10.1159/000130288
State	Published - 1974

ASJC Scopus subject areas

Genetics
Cell Biology

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AU - Liskay, R. M.

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AB - A near diploid mouse cell line has been produced from C57BL/6J X AKR/J F1 hybrid embryonic cells by spontaneous transformation. The modal chromosome number of this line is 41 (2n = 40), with low numerical and structural variation relative to other mouse lines which have been reported. Giemsa banded karyotypes on a number of clones and subclones from this line have been analyzed. The most modal karyotypes deviate very little from that of a normal diploid female. Most of the cells have two X chromosomes, one of which is unlabeled early in the S phase.

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Karyotypic analysis of a near diploid established mouse cell line

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