Lack of suitability of the rabbit model for particulate uterine artery embolization

Christoph A. Binkert; Robert T. Andrews; Dusan Pavcnik; Barry Uchida; Marc M. Loriaux; Naoyuki Toyota; Josef Rösch

doi:10.1016/S1051-0443(07)61655-8

Lack of suitability of the rabbit model for particulate uterine artery embolization

Christoph A. Binkert, Robert T. Andrews, Dusan Pavcnik, Barry Uchida, Marc M. Loriaux, Naoyuki Toyota, Josef Rösch

Pathology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

PURPOSE: The goal of this study was to evaluate the rabbit model for studies of particulate uterine artery embolization (UAE). Rabbits were chosen because it was believed that their year-round breeding time and short duration of pregnancy would be useful in studies of fertility and pregnancy after UAE. MATERIALS AND METHODS: Bilateral UAE was performed in 12 adult female New Zealand White rabbits weighing 4-5.2 kg. All animals were proven to be breeders before treatment. Each uterine artery was embolized to stasis with use of 180-300-μm polyvinyl alcohol (PVA) particles (n = 9 animals), 500-710-μm PVA particles (n = 1), or tris-acryl 500-700-μm gelatin microspheres (n = 2). RESULTS: Two rabbits died 7 days after embolization and the other 10 rabbits had to be killed because of malaise and weight loss 4-8 d after embolization. In all animals, necropsy demonstrated extensive uterine necrosis sparing only the tip of the uterine horn. CONCLUSION: Rabbits are an unsuitable model for studies of UAE with the embolic agents in clinical use.

Original language	English (US)
Article number	61655
Pages (from-to)	609-612
Number of pages	4
Journal	Journal of Vascular and Interventional Radiology
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/S1051-0443(07)61655-8
State	Published - 2002

Keywords

Fibroid
Uterine arteries, embolization
Uterus, neoplasms

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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title = "Lack of suitability of the rabbit model for particulate uterine artery embolization",

abstract = "PURPOSE: The goal of this study was to evaluate the rabbit model for studies of particulate uterine artery embolization (UAE). Rabbits were chosen because it was believed that their year-round breeding time and short duration of pregnancy would be useful in studies of fertility and pregnancy after UAE. MATERIALS AND METHODS: Bilateral UAE was performed in 12 adult female New Zealand White rabbits weighing 4-5.2 kg. All animals were proven to be breeders before treatment. Each uterine artery was embolized to stasis with use of 180-300-μm polyvinyl alcohol (PVA) particles (n = 9 animals), 500-710-μm PVA particles (n = 1), or tris-acryl 500-700-μm gelatin microspheres (n = 2). RESULTS: Two rabbits died 7 days after embolization and the other 10 rabbits had to be killed because of malaise and weight loss 4-8 d after embolization. In all animals, necropsy demonstrated extensive uterine necrosis sparing only the tip of the uterine horn. CONCLUSION: Rabbits are an unsuitable model for studies of UAE with the embolic agents in clinical use.",

keywords = "Fibroid, Uterine arteries, embolization, Uterus, neoplasms",

author = "Binkert, {Christoph A.} and Andrews, {Robert T.} and Dusan Pavcnik and Barry Uchida and Loriaux, {Marc M.} and Naoyuki Toyota and Josef R{\"o}sch",

year = "2002",

doi = "10.1016/S1051-0443(07)61655-8",

language = "English (US)",

volume = "13",

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AU - Binkert, Christoph A.

AU - Andrews, Robert T.

AU - Pavcnik, Dusan

AU - Uchida, Barry

AU - Loriaux, Marc M.

AU - Toyota, Naoyuki

AU - Rösch, Josef

PY - 2002

Y1 - 2002

N2 - PURPOSE: The goal of this study was to evaluate the rabbit model for studies of particulate uterine artery embolization (UAE). Rabbits were chosen because it was believed that their year-round breeding time and short duration of pregnancy would be useful in studies of fertility and pregnancy after UAE. MATERIALS AND METHODS: Bilateral UAE was performed in 12 adult female New Zealand White rabbits weighing 4-5.2 kg. All animals were proven to be breeders before treatment. Each uterine artery was embolized to stasis with use of 180-300-μm polyvinyl alcohol (PVA) particles (n = 9 animals), 500-710-μm PVA particles (n = 1), or tris-acryl 500-700-μm gelatin microspheres (n = 2). RESULTS: Two rabbits died 7 days after embolization and the other 10 rabbits had to be killed because of malaise and weight loss 4-8 d after embolization. In all animals, necropsy demonstrated extensive uterine necrosis sparing only the tip of the uterine horn. CONCLUSION: Rabbits are an unsuitable model for studies of UAE with the embolic agents in clinical use.

AB - PURPOSE: The goal of this study was to evaluate the rabbit model for studies of particulate uterine artery embolization (UAE). Rabbits were chosen because it was believed that their year-round breeding time and short duration of pregnancy would be useful in studies of fertility and pregnancy after UAE. MATERIALS AND METHODS: Bilateral UAE was performed in 12 adult female New Zealand White rabbits weighing 4-5.2 kg. All animals were proven to be breeders before treatment. Each uterine artery was embolized to stasis with use of 180-300-μm polyvinyl alcohol (PVA) particles (n = 9 animals), 500-710-μm PVA particles (n = 1), or tris-acryl 500-700-μm gelatin microspheres (n = 2). RESULTS: Two rabbits died 7 days after embolization and the other 10 rabbits had to be killed because of malaise and weight loss 4-8 d after embolization. In all animals, necropsy demonstrated extensive uterine necrosis sparing only the tip of the uterine horn. CONCLUSION: Rabbits are an unsuitable model for studies of UAE with the embolic agents in clinical use.

KW - Fibroid

KW - Uterine arteries, embolization

KW - Uterus, neoplasms

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Lack of suitability of the rabbit model for particulate uterine artery embolization

Abstract

Keywords

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