LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models

Yoko Yamakoshi; Hui Qiao; Andrew N. Lowell; Mark Woods; Betty Paulose; Yuka Nakao; Hualei Zhang; Ting Liu; Sissel Lund-Katz; Rong Zhou

doi:10.1039/c1cc10924c

LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models

Yoko Yamakoshi, Hui Qiao, Andrew N. Lowell, Mark Woods, Betty Paulose, Yuka Nakao, Hualei Zhang, Ting Liu, Sissel Lund-Katz, Rong Zhou

Advanced Imaging Research Center

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.

Original language	English (US)
Pages (from-to)	8835-8837
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	31
DOIs	https://doi.org/10.1039/c1cc10924c
State	Published - Aug 21 2011

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc10924c

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abstract = "A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.",

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AU - Yamakoshi, Yoko

AU - Qiao, Hui

AU - Lowell, Andrew N.

AU - Woods, Mark

AU - Paulose, Betty

AU - Nakao, Yuka

AU - Zhang, Hualei

AU - Liu, Ting

AU - Lund-Katz, Sissel

AU - Zhou, Rong

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AB - A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.

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LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models

Abstract

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