Leveraging Hypomethylating Agents for Better MDS Therapy

Terrence J. Bradley, Justin M. Watts, Ronan T. Swords

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: Myelodysplastic syndrome (MDS) is a clinically and molecularly heterogeneous disease, which primarily occurs in older adults. Although hypomethylating agents have survival benefit and are the current standard of care, many MDS patients will not garner a response from therapy. For those who do respond, most responses are not durable, and the only hope for a cure is allogeneic stem cell transplant. New therapies to improve outcomes are urgently needed. Recent Findings: Clinical trials combining standard hypomethylating agents with novel experimental agents are underway in an effort to improve clinical outcomes in MDS patients. Several of these small molecules have demonstrated the ability to augment the response rates of hypomethylating agents alone, including complete remission rates, in both the front line and refractory settings. Summary: Combination approaches utilizing hypomethylating agents and novel-targeted therapies have demonstrated the ability to improve response rates in MDS patients in both the front line and salvage settings, and thus may change the standard of care.

Original languageEnglish (US)
Pages (from-to)507-515
Number of pages9
JournalCurrent Hematologic Malignancy Reports
Issue number6
StatePublished - Dec 1 2018
Externally publishedYes


  • Acute myeloid leukemia
  • Hypomethylating agents
  • Immunotherapy
  • Isocitrate dehydrogenase
  • Myelodysplastic syndrome
  • Pevonedistat

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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