Ligneous Conjunctivitis With Ear Involvement

Dennis M. Marcus, David Walton, Peter Donshik, Lisa Choo, Richard A. Newman, Daniel M. Albert

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


We report the association of ligneous conjunctivitis with middle-ear and tympanic membrane involvement in two children. Eye and ear specimens revealed histopathologic and ultrastructural findings consistent with ligneous conjunctivitis, characterized by an amorphous, eosinophilic material with acute and chronic non-granulomatous inflammation. Ear specimens demonstrated granulation tissue along with the above features. Conjunctival and ear lesions from these patients were studied histochemically, immunohistochemically, and ultrastructurally. Our studies demonstrate fibrin and albumin deposition as a common feature in all lesions. Deposition of other components, such as mucopolysaccharides, amyloid, immunoglobulins, and mast cells, were, however, variable. The diversified nature of these lesions, together with the association of eye and ear disease, substantiates the existence of an underlying systemic disorder of unknown cause.

Original languageEnglish (US)
Pages (from-to)514-519
Number of pages6
JournalArchives of ophthalmology
Issue number4
StatePublished - Apr 1990
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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