Liquid nitrogen cryotherapy of advancing wavelike epitheliopathy

Frederick Web Fraunfelder

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Purpose: To describe a method for treating advancing wavelike epitheliopathy (AWE) with liquid nitrogen cryotherapy spray. Methods: A Brymill® liquid nitrogen cryotherapy canister with a "D" tip was used to freeze AWE in 5 cases in 4 patients. Freezing time was approximately 1-2 seconds and was performed twice. The affected limbus and corneal epithelium were treated in this manner. Results: In each case, AWE resolved within 2 weeks, with no recurrence at 1 year. Conclusion: Liquid nitrogen cryotherapy is a safe and effective treatment of advancing wavelike epithelopathy.

Original languageEnglish (US)
Pages (from-to)196-198
Number of pages3
Issue number2
StatePublished - Feb 2006


  • AWE
  • Advancing wavelike epitheliopathy
  • Liquid nitrogen cryotherapy

ASJC Scopus subject areas

  • Ophthalmology


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