Liver repair and hemorrhage control by using laser soldering of liquid albumin in a porcine model

Yasmin Wadia, Hua Xie, Michio Kajitani

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Background and Objective: We evaluated laser soldering by using liquid albumin for welding liver injuries. Major liver trauma has a high mortality because of immediate exsanguination and a delayed morbidity from septicemia, peritonitis, biliary fistulae, and delayed secondary hemorrhage. Study Design/Materials and Methods: Eight laceration (6 x 2 cm) and eight nonanatomic resection injuries (raw surface, 6 x 2 cm) were repaired. An 805-nm laser was used to weld 50% liquid albuminindocyanine green solder to the liver surface, reinforcing it with a free autologous omental scaffold. The animals were heparinized and hepatic inflow occlusion was used for vascular control. All 16 soldering repairs were evaluated at 3 hours. Results: All 16 laser mediated liver repairs had minimal blood loss as compared with the suture controls. No dehiscence, hemorrhage, or bile leakage was seen in any of the laser repairs after 3 hours. Conclusion: Laser fusion repair of the liver is a reliable technique to gain hemostasis on the raw surface as well as weld lacerations. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)319-328
Number of pages10
JournalLasers in Surgery and Medicine
Issue number4
StatePublished - 2000


  • Albumin solder
  • Indocyanine green
  • Liver trauma
  • Tissue welding

ASJC Scopus subject areas

  • Surgery
  • Dermatology


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