@article{9e70349b4f644d5abe0dbb7499adb49b,
title = "Local μ-Opioid Receptor Antagonism Blunts Evoked Phasic Dopamine Release in the Nucleus Accumbens of Rats",
abstract = "μ-opioid receptors (MORs) in the nucleus accumbens (NAc) can regulate reward-related behaviors that are dependent on mesolimbic dopamine, but the precise mechanism of this MOR regulation is unknown. We hypothesized that MORs within the NAc core regulate dopamine release. Specifically, we infused the MOR antagonist CTAP (d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2) into the NAc core while dopamine release was evoked by electrical stimulation of the ventral tegmental area and measured by fast-scan cyclic voltammetry. We report that CTAP dose-dependently inhibited evoked dopamine release, with full blockade achieved with the 8 μg infusion. In contrast, evoked dopamine release increased after nomifensine infusion and was unchanged after vehicle infusion. These findings demonstrate profound local control of dopamine release by MORs within the NAc core, which has implications for regulation of reward processing.",
keywords = "accumbens, dopamine, electrochemistry, local infusion, phasic, μ-opioid receptor",
author = "Alexander G{\'o}mez-A and Shnitko, {Tatiana A.} and Barefoot, {Haley M.} and Brightbill, {Eleanor L.} and Sombers, {Leslie A.} and Nicola, {Saleem M.} and Robinson, {Donita L.}",
note = "Funding Information: *D. L. Robinson. Phone: 1+ 919-966-9178. ORCID Eleanor L. Brightbill: 0000-0003-2324-756X Leslie A. Sombers: 0000-0002-0978-9795 Donita L. Robinson: 0000-0001-7540-3363 Author Contributions T.A.S., D.L.R., L.A.S., and S.M.N. designed the studies. T.A.S., A.G.A., E.L.B., and H.M.B. collected and analyzed the data. L.A.S. developed the infusion technique and provided training. D.L.R., A.G.A., and S.M.N. interpreted the data. A.G.A., H.M.B., T.A.S., S.M.N., and D.L.R. wrote the manuscript. All authors edited and approved the manuscript. Funding This research was funded by a Klarman Family Foundation grant to S.M.N. and by the UNC Bowles Center for Alcohol Studies. E.L.B. was supported by a Summer Undergraduate Research Fellowship from the Office for Undergraduate Research at the University of North Carolina at Chapel Hill. Notes The authors declare no competing financial interest. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2019",
month = apr,
day = "17",
doi = "10.1021/acschemneuro.8b00437",
language = "English (US)",
volume = "10",
pages = "1935--1940",
journal = "ACS Chemical Neuroscience",
issn = "1948-7193",
publisher = "American Chemical Society",
number = "4",
}