Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Bahareh Ajami; Jami L. Bennett; Charles Krieger; Wolfram Tetzlaff; Fabio M.V. Rossi

doi:10.1038/nn2014

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Bahareh Ajami, Jami L. Bennett, Charles Krieger, Wolfram Tetzlaff, Fabio M.V. Rossi

Research output: Contribution to journal › Article › peer-review

1219 Scopus citations

Abstract

Microgliosis is a common response to multiple types of damage in the CNS. However, the origin of the cells involved in this process is still controversial and the relative importance of local expansion versus recruitment of microglia progenitors from the bloodstream is unclear. Here, we investigated the origin of microglia using chimeric animals obtained by parabiosis. We found no evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease, suggesting that maintenance and local expansion of microglia are solely dependent on the self-renewal of CNS resident cells in these models.

Original language	English (US)
Pages (from-to)	1538-1543
Number of pages	6
Journal	Nature Neuroscience
Volume	10
Issue number	12
DOIs	https://doi.org/10.1038/nn2014
State	Published - Dec 2007
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1038/nn2014

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title = "Local self-renewal can sustain CNS microglia maintenance and function throughout adult life",

abstract = "Microgliosis is a common response to multiple types of damage in the CNS. However, the origin of the cells involved in this process is still controversial and the relative importance of local expansion versus recruitment of microglia progenitors from the bloodstream is unclear. Here, we investigated the origin of microglia using chimeric animals obtained by parabiosis. We found no evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease, suggesting that maintenance and local expansion of microglia are solely dependent on the self-renewal of CNS resident cells in these models.",

author = "Bahareh Ajami and Bennett, {Jami L.} and Charles Krieger and Wolfram Tetzlaff and Rossi, {Fabio M.V.}",

note = "Funding Information: K.M. McNagny for critical evaluation of the manuscript. This work was supported by Canadian Institute for Health Research (CIHR) grants to F.M.V.R. (MOP 81382) and to W.T. (MOP 42480), a Neuromuscular Research Partnership grant from CIHR, a ALS Society of Canada and Muscular Dystrophy Canada grant to C.K. and F.M.V.R. (JNM-69682) and a Collaborative Health Research Grant from CIHR and Natural Science and Engineering Research Council to C.K. and F.M.V.R. (CHRP 299119). J.L.B. is supported by a Multiple Sclerosis Society of Canada Postdoctoral Research Fellowship.",

year = "2007",

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doi = "10.1038/nn2014",

language = "English (US)",

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pages = "1538--1543",

journal = "Nature Neuroscience",

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T1 - Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

AU - Ajami, Bahareh

AU - Bennett, Jami L.

AU - Krieger, Charles

AU - Tetzlaff, Wolfram

AU - Rossi, Fabio M.V.

N1 - Funding Information: K.M. McNagny for critical evaluation of the manuscript. This work was supported by Canadian Institute for Health Research (CIHR) grants to F.M.V.R. (MOP 81382) and to W.T. (MOP 42480), a Neuromuscular Research Partnership grant from CIHR, a ALS Society of Canada and Muscular Dystrophy Canada grant to C.K. and F.M.V.R. (JNM-69682) and a Collaborative Health Research Grant from CIHR and Natural Science and Engineering Research Council to C.K. and F.M.V.R. (CHRP 299119). J.L.B. is supported by a Multiple Sclerosis Society of Canada Postdoctoral Research Fellowship.

PY - 2007/12

Y1 - 2007/12

N2 - Microgliosis is a common response to multiple types of damage in the CNS. However, the origin of the cells involved in this process is still controversial and the relative importance of local expansion versus recruitment of microglia progenitors from the bloodstream is unclear. Here, we investigated the origin of microglia using chimeric animals obtained by parabiosis. We found no evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease, suggesting that maintenance and local expansion of microglia are solely dependent on the self-renewal of CNS resident cells in these models.

AB - Microgliosis is a common response to multiple types of damage in the CNS. However, the origin of the cells involved in this process is still controversial and the relative importance of local expansion versus recruitment of microglia progenitors from the bloodstream is unclear. Here, we investigated the origin of microglia using chimeric animals obtained by parabiosis. We found no evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease, suggesting that maintenance and local expansion of microglia are solely dependent on the self-renewal of CNS resident cells in these models.

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JF - Nature Neuroscience

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Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Abstract

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