Localization of GRF-like immunoreactive neurons in the rat brain

David M. Jacobowitz; Heinrich Schulte; George P. Chrousos; D. Lynn Loriaux

doi:10.1016/0196-9781(83)90058-X

Localization of GRF-like immunoreactive neurons in the rat brain

David M. Jacobowitz, Heinrich Schulte, George P. Chrousos, D. Lynn Loriaux

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

The localization of human GRF_1-44-immunoreactive neurons was studied in the rat brain. A dense accumulation of GRF-containing fibers was noted in the external layer of the median eminence. Cell bodies were observed in colchicine-treated rats. The most intensely fluorescent cluster of cells was contained in the arcuate nucleus. Other cells were seen on the base of the hypothalamus, within the median forebrain bundle, dorsal and ventral aspects of the ventromedial nucleus, zona incerta and dorsal part of the dorsomedial nucleus. These cells may influence the pulsatile release of pituitary growth hormone.

Original language	English (US)
Pages (from-to)	521-524
Number of pages	4
Journal	Peptides
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/0196-9781(83)90058-X
State	Published - 1983
Externally published	Yes

Keywords

Arcuate nucleus
GRF
Growth hormone releasing factor
Immunocytochemistry
Median eminence

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(83)90058-X

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title = "Localization of GRF-like immunoreactive neurons in the rat brain",

abstract = "The localization of human GRF1-44-immunoreactive neurons was studied in the rat brain. A dense accumulation of GRF-containing fibers was noted in the external layer of the median eminence. Cell bodies were observed in colchicine-treated rats. The most intensely fluorescent cluster of cells was contained in the arcuate nucleus. Other cells were seen on the base of the hypothalamus, within the median forebrain bundle, dorsal and ventral aspects of the ventromedial nucleus, zona incerta and dorsal part of the dorsomedial nucleus. These cells may influence the pulsatile release of pituitary growth hormone.",

keywords = "Arcuate nucleus, GRF, Growth hormone releasing factor, Immunocytochemistry, Median eminence",

author = "Jacobowitz, {David M.} and Heinrich Schulte and Chrousos, {George P.} and {Lynn Loriaux}, D.",

year = "1983",

doi = "10.1016/0196-9781(83)90058-X",

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T1 - Localization of GRF-like immunoreactive neurons in the rat brain

AU - Jacobowitz, David M.

AU - Schulte, Heinrich

AU - Chrousos, George P.

AU - Lynn Loriaux, D.

PY - 1983

Y1 - 1983

N2 - The localization of human GRF1-44-immunoreactive neurons was studied in the rat brain. A dense accumulation of GRF-containing fibers was noted in the external layer of the median eminence. Cell bodies were observed in colchicine-treated rats. The most intensely fluorescent cluster of cells was contained in the arcuate nucleus. Other cells were seen on the base of the hypothalamus, within the median forebrain bundle, dorsal and ventral aspects of the ventromedial nucleus, zona incerta and dorsal part of the dorsomedial nucleus. These cells may influence the pulsatile release of pituitary growth hormone.

AB - The localization of human GRF1-44-immunoreactive neurons was studied in the rat brain. A dense accumulation of GRF-containing fibers was noted in the external layer of the median eminence. Cell bodies were observed in colchicine-treated rats. The most intensely fluorescent cluster of cells was contained in the arcuate nucleus. Other cells were seen on the base of the hypothalamus, within the median forebrain bundle, dorsal and ventral aspects of the ventromedial nucleus, zona incerta and dorsal part of the dorsomedial nucleus. These cells may influence the pulsatile release of pituitary growth hormone.

KW - Arcuate nucleus

KW - GRF

KW - Growth hormone releasing factor

KW - Immunocytochemistry

KW - Median eminence

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DO - 10.1016/0196-9781(83)90058-X

M3 - Article

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AN - SCOPUS:0021040730

SN - 0196-9781

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SP - 521

EP - 524

JO - Peptides

JF - Peptides

IS - 4

ER -

Localization of GRF-like immunoreactive neurons in the rat brain

Abstract

Keywords

ASJC Scopus subject areas

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