Localization of GRF-like immunoreactive neurons in the rat brain

David M. Jacobowitz, Heinrich Schulte, George P. Chrousos, D. Lynn Loriaux

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


The localization of human GRF1-44-immunoreactive neurons was studied in the rat brain. A dense accumulation of GRF-containing fibers was noted in the external layer of the median eminence. Cell bodies were observed in colchicine-treated rats. The most intensely fluorescent cluster of cells was contained in the arcuate nucleus. Other cells were seen on the base of the hypothalamus, within the median forebrain bundle, dorsal and ventral aspects of the ventromedial nucleus, zona incerta and dorsal part of the dorsomedial nucleus. These cells may influence the pulsatile release of pituitary growth hormone.

Original languageEnglish (US)
Pages (from-to)521-524
Number of pages4
Issue number4
StatePublished - 1983
Externally publishedYes


  • Arcuate nucleus
  • GRF
  • Growth hormone releasing factor
  • Immunocytochemistry
  • Median eminence

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience


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