Localization of two potassium channel β subunit genes, KCNA1B and KCNA2B

Dennis Schultz; Michael Litt; Leslie Smith; Mathew Thayer; Ken Mccormack

doi:10.1006/geno.1996.0065

Localization of two potassium channel β subunit genes, KCNA1B and KCNA2B

Dennis Schultz, Michael Litt, Leslie Smith, Mathew Thayer, Ken Mccormack

Chemical Physiology and Biochemistry

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The gating properties and current amplitudes of mammalian voltage- activated Shaker potassium channels are modulated by at least two associated β subunits (Kvβ1.1 and Kvβ1.2). The human Kvβ1.1 gene (KCNA1B) resides on chromosome 3, as indicated by somatic cell hybrid mapping. More precise localization of KCNA1B to 3q26.1 was obtained with fluorescence in situ hybridization (FISH) and was corroborated by PCR screening of the CEPH YAC library. The human Kvβ1.2 gene (KCNA2β) resides on chromosome 1, as indicated by somatic cell hybrid mapping, and has been localized by FISH to 1p36.3.

Original language	English (US)
Pages (from-to)	389-391
Number of pages	3
Journal	Genomics
Volume	31
Issue number	3
DOIs	https://doi.org/10.1006/geno.1996.0065
State	Published - Feb 1 1996

ASJC Scopus subject areas

Genetics

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10.1006/geno.1996.0065

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title = "Localization of two potassium channel β subunit genes, KCNA1B and KCNA2B",

abstract = "The gating properties and current amplitudes of mammalian voltage- activated Shaker potassium channels are modulated by at least two associated β subunits (Kvβ1.1 and Kvβ1.2). The human Kvβ1.1 gene (KCNA1B) resides on chromosome 3, as indicated by somatic cell hybrid mapping. More precise localization of KCNA1B to 3q26.1 was obtained with fluorescence in situ hybridization (FISH) and was corroborated by PCR screening of the CEPH YAC library. The human Kvβ1.2 gene (KCNA2β) resides on chromosome 1, as indicated by somatic cell hybrid mapping, and has been localized by FISH to 1p36.3.",

author = "Dennis Schultz and Michael Litt and Leslie Smith and Mathew Thayer and Ken Mccormack",

note = "Funding Information: This work was supported by NIH Grants HG00022 (to M.L.) and GM49334 (to M.T.). K.M. was supported by a long-term HFSP fellowship. We are grateful to Walter Stuehmer and Linda Iverson, in whose laboratories some of this work was completed.",

year = "1996",

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doi = "10.1006/geno.1996.0065",

language = "English (US)",

volume = "31",

pages = "389--391",

journal = "Genomics",

issn = "0888-7543",

publisher = "Academic Press Inc.",

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T1 - Localization of two potassium channel β subunit genes, KCNA1B and KCNA2B

AU - Schultz, Dennis

AU - Litt, Michael

AU - Smith, Leslie

AU - Thayer, Mathew

AU - Mccormack, Ken

N1 - Funding Information: This work was supported by NIH Grants HG00022 (to M.L.) and GM49334 (to M.T.). K.M. was supported by a long-term HFSP fellowship. We are grateful to Walter Stuehmer and Linda Iverson, in whose laboratories some of this work was completed.

PY - 1996/2/1

Y1 - 1996/2/1

N2 - The gating properties and current amplitudes of mammalian voltage- activated Shaker potassium channels are modulated by at least two associated β subunits (Kvβ1.1 and Kvβ1.2). The human Kvβ1.1 gene (KCNA1B) resides on chromosome 3, as indicated by somatic cell hybrid mapping. More precise localization of KCNA1B to 3q26.1 was obtained with fluorescence in situ hybridization (FISH) and was corroborated by PCR screening of the CEPH YAC library. The human Kvβ1.2 gene (KCNA2β) resides on chromosome 1, as indicated by somatic cell hybrid mapping, and has been localized by FISH to 1p36.3.

AB - The gating properties and current amplitudes of mammalian voltage- activated Shaker potassium channels are modulated by at least two associated β subunits (Kvβ1.1 and Kvβ1.2). The human Kvβ1.1 gene (KCNA1B) resides on chromosome 3, as indicated by somatic cell hybrid mapping. More precise localization of KCNA1B to 3q26.1 was obtained with fluorescence in situ hybridization (FISH) and was corroborated by PCR screening of the CEPH YAC library. The human Kvβ1.2 gene (KCNA2β) resides on chromosome 1, as indicated by somatic cell hybrid mapping, and has been localized by FISH to 1p36.3.

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DO - 10.1006/geno.1996.0065

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EP - 391

JO - Genomics

JF - Genomics

IS - 3

ER -

Localization of two potassium channel β subunit genes, KCNA1B and KCNA2B

Abstract

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