Locomotor activity predicts acquisition of self-administration behavior but not cocaine intake

Jennifer M. Mitchell, Chris L. Cunningham, Gregory P. Mark

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


The current study investigates locomotor activity in a novel environment and correlates these activity levels with cocaine self-administration in rats that were either trained or untrained on a lever-pressing task prior to cocaine self-administration. The authors report that it is the rate of learning the lever-pressing task, not cocaine self-administration, that correlates with locomotor activity. The results suggest that a correlation between locomotor activity and cocaine self-administration is secondary to a link between locomotor activity and rate of learning to lever press for a reward. The authors conclude that locomotor activity is not necessarily an indicator of propensity to self-administer cocaine and demonstrate that environmental novelty and rate of learning an operant task are important considerations when designing experiments on drug-seeking behaviors.

Original languageEnglish (US)
Pages (from-to)464-472
Number of pages9
JournalBehavioral Neuroscience
Issue number2
StatePublished - Apr 2005
Externally publishedYes


  • Addiction
  • Cocaine
  • Learning
  • Locomotion
  • Self-administration

ASJC Scopus subject areas

  • Behavioral Neuroscience


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