Long-Term Depression (LTD): Metabotropic Glutamate Receptor (mGluR) and NMDAR-Dependent Forms

C. Lüscher, M. Frerking

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Long-term depression (LTD) of excitatory synaptic transmission represents a mechanism by which synapses can undergo an activity-dependent weakening of their strength. There are at least two broad classes of LTD, distinguished by the glutamate receptor that is required for LTD induction, which may be either of the NMDA (NMDAR) or metabotropic (mGluR) type. For this article we therefore distinguish NMDAR-LTD from mGluR-LTD and present contrasting properties for their induction, expression, and maintenance.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Number of pages6
ISBN (Print)9780080450469
StatePublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Long-Term Depression (LTD): Metabotropic Glutamate Receptor (mGluR) and NMDAR-Dependent Forms'. Together they form a unique fingerprint.

Cite this