Long-term quality of life after treatment in sinonasal malignancy: A prospective, multicenter study

Sabrina L. Maoz; Eric W. Wang; Peter H. Hwang; Garret Choby; Edward C. Kuan; Cara M. Fleseriu; Erik P. Chan; Nithin D. Adappa; Mathew Geltzeiler; Anne E. Getz; Ian M. Humphreys; Christopher H. Le; Waleed M. Abuzeid; Eugene H. Chang; Aria Jafari; Todd T. Kingdom; Michael A. Kohanski; Jivianne K. Lee; Jillian W. Lazor; Ali Nabavizadeh; Jayakar V. Nayak; James N. Palmer; Zara M. Patel; Carlos D. Pinheiro-Neto; Adam C. Resnick; Timothy L. Smith; Carl H. Snyderman; Maie A. St. John; Phillip B. Storm; Jeffrey D. Suh; Marilene B. Wang; Myung S. Sim; Daniel M. Beswick

doi:10.1002/alr.23171

Long-term quality of life after treatment in sinonasal malignancy: A prospective, multicenter study

Sabrina L. Maoz, Eric W. Wang, Peter H. Hwang, Garret Choby, Edward C. Kuan, Cara M. Fleseriu, Erik P. Chan, Nithin D. Adappa, Mathew Geltzeiler, Anne E. Getz, Ian M. Humphreys, Christopher H. Le, Waleed M. Abuzeid, Eugene H. Chang, Aria Jafari, Todd T. Kingdom, Michael A. Kohanski, Jivianne K. Lee, Jillian W. Lazor, Ali NabavizadehJayakar V. Nayak, James N. Palmer, Zara M. Patel, Carlos D. Pinheiro-Neto, Adam C. Resnick, Timothy L. Smith, Carl H. Snyderman, Maie A. St. John, Phillip B. Storm, Jeffrey D. Suh, Marilene B. Wang, Myung S. Sim, Daniel M. Beswick

Otolaryngology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Quality of life (QOL) for individuals with sinonasal malignancy (SNM) is significantly under-studied, yet it is critical for counseling and may impact treatment. In this study we evaluated how patient, treatment, and disease factors impact sinonasal-specific and generalized QOL using validated metrics in a large cohort over a 5-year posttreatment time frame. Methods: Patients with SNM who underwent definitive treatment with curative intent were enrolled in a prospective, multisite, longitudinal observational study. QOL was assessed using the 22-item Sino-Nasal Outcome Test (SNOT-22) and University of Washington Quality of Life Questionnaire (UWQOL) instruments at pretreatment baseline and multiple follow-ups through 5 years posttreatment. Multivariable modeling was used to determine demographic, disease, and treatment factors associated with disease-specific and generalized physical and social/emotional function QOL. Results: One hundred ninety-four patients with SNM were analyzed. All QOL indices were impaired at pretreatment baseline and improved after treatment. SNOT-22 scores improved 3 months and UWQOL scores improved 6 to 9 months posttreatment. Patients who underwent open compared with endoscopic tumor resection had worse generalized QOL (p < 0.001), adjusted for factors including T stage. Pterygopalatine fossa (PPF) involvement was associated with worse QOL (SNOT-22, p < 0.001; UWQOL Physical dimension, p = 0.02). Adjuvant radiation was associated with worse disease-specific QOL (p = 0.03). Neck dissection was associated with worse generalized physical function QOL (p = 0.01). Positive margins were associated with worse generalized social/emotional function QOL (p = 0.01). Conclusion: Disease-specific and generalized QOL is impaired at baseline in patients with SNM and improves after treatment. Endoscopic resection is associated with better QOL. PPF involvement, adjuvant radiation, neck dissection, and positive margins were associated with worse QOL posttreatment.

Original language	English (US)
Pages (from-to)	2030-2042
Number of pages	13
Journal	International Forum of Allergy and Rhinology
Volume	13
Issue number	11
DOIs	https://doi.org/10.1002/alr.23171
State	Published - Nov 2023

Keywords

head and neck cancer
quality of life
sinonasal cancer

ASJC Scopus subject areas

Immunology and Allergy
Otorhinolaryngology

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10.1002/alr.23171

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Maoz, S. L., Wang, E. W., Hwang, P. H., Choby, G., Kuan, E. C., Fleseriu, C. M., Chan, E. P., Adappa, N. D., Geltzeiler, M., Getz, A. E., Humphreys, I. M., Le, C. H., Abuzeid, W. M., Chang, E. H., Jafari, A., Kingdom, T. T., Kohanski, M. A., Lee, J. K., Lazor, J. W., ... Beswick, D. M. (2023). Long-term quality of life after treatment in sinonasal malignancy: A prospective, multicenter study. International Forum of Allergy and Rhinology, 13(11), 2030-2042. https://doi.org/10.1002/alr.23171

Maoz, SL, Wang, EW, Hwang, PH, Choby, G, Kuan, EC, Fleseriu, CM, Chan, EP, Adappa, ND, Geltzeiler, M, Getz, AE, Humphreys, IM, Le, CH, Abuzeid, WM, Chang, EH, Jafari, A, Kingdom, TT, Kohanski, MA, Lee, JK, Lazor, JW, Nabavizadeh, A, Nayak, JV, Palmer, JN, Patel, ZM, Pinheiro-Neto, CD, Resnick, AC, Smith, TL, Snyderman, CH, St. John, MA, Storm, PB, Suh, JD, Wang, MB, Sim, MS & Beswick, DM 2023, 'Long-term quality of life after treatment in sinonasal malignancy: A prospective, multicenter study', International Forum of Allergy and Rhinology, vol. 13, no. 11, pp. 2030-2042. https://doi.org/10.1002/alr.23171

@article{105a275b97e943e2b487018bc4bc35f2,

title = "Long-term quality of life after treatment in sinonasal malignancy: A prospective, multicenter study",

abstract = "Background: Quality of life (QOL) for individuals with sinonasal malignancy (SNM) is significantly under-studied, yet it is critical for counseling and may impact treatment. In this study we evaluated how patient, treatment, and disease factors impact sinonasal-specific and generalized QOL using validated metrics in a large cohort over a 5-year posttreatment time frame. Methods: Patients with SNM who underwent definitive treatment with curative intent were enrolled in a prospective, multisite, longitudinal observational study. QOL was assessed using the 22-item Sino-Nasal Outcome Test (SNOT-22) and University of Washington Quality of Life Questionnaire (UWQOL) instruments at pretreatment baseline and multiple follow-ups through 5 years posttreatment. Multivariable modeling was used to determine demographic, disease, and treatment factors associated with disease-specific and generalized physical and social/emotional function QOL. Results: One hundred ninety-four patients with SNM were analyzed. All QOL indices were impaired at pretreatment baseline and improved after treatment. SNOT-22 scores improved 3 months and UWQOL scores improved 6 to 9 months posttreatment. Patients who underwent open compared with endoscopic tumor resection had worse generalized QOL (p < 0.001), adjusted for factors including T stage. Pterygopalatine fossa (PPF) involvement was associated with worse QOL (SNOT-22, p < 0.001; UWQOL Physical dimension, p = 0.02). Adjuvant radiation was associated with worse disease-specific QOL (p = 0.03). Neck dissection was associated with worse generalized physical function QOL (p = 0.01). Positive margins were associated with worse generalized social/emotional function QOL (p = 0.01). Conclusion: Disease-specific and generalized QOL is impaired at baseline in patients with SNM and improves after treatment. Endoscopic resection is associated with better QOL. PPF involvement, adjuvant radiation, neck dissection, and positive margins were associated with worse QOL posttreatment.",

keywords = "head and neck cancer, quality of life, sinonasal cancer",

author = "Maoz, {Sabrina L.} and Wang, {Eric W.} and Hwang, {Peter H.} and Garret Choby and Kuan, {Edward C.} and Fleseriu, {Cara M.} and Chan, {Erik P.} and Adappa, {Nithin D.} and Mathew Geltzeiler and Getz, {Anne E.} and Humphreys, {Ian M.} and Le, {Christopher H.} and Abuzeid, {Waleed M.} and Chang, {Eugene H.} and Aria Jafari and Kingdom, {Todd T.} and Kohanski, {Michael A.} and Lee, {Jivianne K.} and Lazor, {Jillian W.} and Ali Nabavizadeh and Nayak, {Jayakar V.} and Palmer, {James N.} and Patel, {Zara M.} and Pinheiro-Neto, {Carlos D.} and Resnick, {Adam C.} and Smith, {Timothy L.} and Snyderman, {Carl H.} and {St. John}, {Maie A.} and Storm, {Phillip B.} and Suh, {Jeffrey D.} and Wang, {Marilene B.} and Sim, {Myung S.} and Beswick, {Daniel M.}",

note = "Publisher Copyright: {\textcopyright} 2023 ARS-AAOA, LLC.",

year = "2023",

month = nov,

doi = "10.1002/alr.23171",

language = "English (US)",

volume = "13",

pages = "2030--2042",

journal = "International Forum of Allergy and Rhinology",

issn = "2042-6976",

publisher = "Wiley-Blackwell",

number = "11",

}

TY - JOUR

T1 - Long-term quality of life after treatment in sinonasal malignancy

T2 - A prospective, multicenter study

AU - Maoz, Sabrina L.

AU - Wang, Eric W.

AU - Hwang, Peter H.

AU - Choby, Garret

AU - Kuan, Edward C.

AU - Fleseriu, Cara M.

AU - Chan, Erik P.

AU - Adappa, Nithin D.

AU - Geltzeiler, Mathew

AU - Getz, Anne E.

AU - Humphreys, Ian M.

AU - Le, Christopher H.

AU - Abuzeid, Waleed M.

AU - Chang, Eugene H.

AU - Jafari, Aria

AU - Kingdom, Todd T.

AU - Kohanski, Michael A.

AU - Lee, Jivianne K.

AU - Lazor, Jillian W.

AU - Nabavizadeh, Ali

AU - Nayak, Jayakar V.

AU - Palmer, James N.

AU - Patel, Zara M.

AU - Pinheiro-Neto, Carlos D.

AU - Resnick, Adam C.

AU - Smith, Timothy L.

AU - Snyderman, Carl H.

AU - St. John, Maie A.

AU - Storm, Phillip B.

AU - Suh, Jeffrey D.

AU - Wang, Marilene B.

AU - Sim, Myung S.

AU - Beswick, Daniel M.

PY - 2023/11

Y1 - 2023/11

N2 - Background: Quality of life (QOL) for individuals with sinonasal malignancy (SNM) is significantly under-studied, yet it is critical for counseling and may impact treatment. In this study we evaluated how patient, treatment, and disease factors impact sinonasal-specific and generalized QOL using validated metrics in a large cohort over a 5-year posttreatment time frame. Methods: Patients with SNM who underwent definitive treatment with curative intent were enrolled in a prospective, multisite, longitudinal observational study. QOL was assessed using the 22-item Sino-Nasal Outcome Test (SNOT-22) and University of Washington Quality of Life Questionnaire (UWQOL) instruments at pretreatment baseline and multiple follow-ups through 5 years posttreatment. Multivariable modeling was used to determine demographic, disease, and treatment factors associated with disease-specific and generalized physical and social/emotional function QOL. Results: One hundred ninety-four patients with SNM were analyzed. All QOL indices were impaired at pretreatment baseline and improved after treatment. SNOT-22 scores improved 3 months and UWQOL scores improved 6 to 9 months posttreatment. Patients who underwent open compared with endoscopic tumor resection had worse generalized QOL (p < 0.001), adjusted for factors including T stage. Pterygopalatine fossa (PPF) involvement was associated with worse QOL (SNOT-22, p < 0.001; UWQOL Physical dimension, p = 0.02). Adjuvant radiation was associated with worse disease-specific QOL (p = 0.03). Neck dissection was associated with worse generalized physical function QOL (p = 0.01). Positive margins were associated with worse generalized social/emotional function QOL (p = 0.01). Conclusion: Disease-specific and generalized QOL is impaired at baseline in patients with SNM and improves after treatment. Endoscopic resection is associated with better QOL. PPF involvement, adjuvant radiation, neck dissection, and positive margins were associated with worse QOL posttreatment.

AB - Background: Quality of life (QOL) for individuals with sinonasal malignancy (SNM) is significantly under-studied, yet it is critical for counseling and may impact treatment. In this study we evaluated how patient, treatment, and disease factors impact sinonasal-specific and generalized QOL using validated metrics in a large cohort over a 5-year posttreatment time frame. Methods: Patients with SNM who underwent definitive treatment with curative intent were enrolled in a prospective, multisite, longitudinal observational study. QOL was assessed using the 22-item Sino-Nasal Outcome Test (SNOT-22) and University of Washington Quality of Life Questionnaire (UWQOL) instruments at pretreatment baseline and multiple follow-ups through 5 years posttreatment. Multivariable modeling was used to determine demographic, disease, and treatment factors associated with disease-specific and generalized physical and social/emotional function QOL. Results: One hundred ninety-four patients with SNM were analyzed. All QOL indices were impaired at pretreatment baseline and improved after treatment. SNOT-22 scores improved 3 months and UWQOL scores improved 6 to 9 months posttreatment. Patients who underwent open compared with endoscopic tumor resection had worse generalized QOL (p < 0.001), adjusted for factors including T stage. Pterygopalatine fossa (PPF) involvement was associated with worse QOL (SNOT-22, p < 0.001; UWQOL Physical dimension, p = 0.02). Adjuvant radiation was associated with worse disease-specific QOL (p = 0.03). Neck dissection was associated with worse generalized physical function QOL (p = 0.01). Positive margins were associated with worse generalized social/emotional function QOL (p = 0.01). Conclusion: Disease-specific and generalized QOL is impaired at baseline in patients with SNM and improves after treatment. Endoscopic resection is associated with better QOL. PPF involvement, adjuvant radiation, neck dissection, and positive margins were associated with worse QOL posttreatment.

KW - head and neck cancer

KW - quality of life

KW - sinonasal cancer

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U2 - 10.1002/alr.23171

DO - 10.1002/alr.23171

M3 - Article

C2 - 37082883

AN - SCOPUS:85158170666

SN - 2042-6976

VL - 13

SP - 2030

EP - 2042

JO - International Forum of Allergy and Rhinology

JF - International Forum of Allergy and Rhinology

IS - 11

ER -

Long-term quality of life after treatment in sinonasal malignancy: A prospective, multicenter study

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