TY - JOUR
T1 - Low-Grade Appendiceal Mucinous Neoplasms
T2 - A Single Institution Experience of 64 Cases With Clinical Follow-up and Correlation With the Current (Eighth Edition) AJCC Staging
AU - Wong, Mary
AU - Barrows, Brad
AU - Gangi, Alexandra
AU - Kim, Stacey
AU - Mertens, Richard B.
AU - Dhall, Deepti
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Background. In this single-institution study, we applied the current (eighth edition) American Joint Committee on Cancer pathologic staging criteria to 64 low-grade mucinous neoplasms of the appendix (LAMNs), examined their histopathologic features, and studied the patients’ clinical outcomes. Design. Sixty-four LAMNs, with a median follow-up of 52 months, were reviewed. Results. The distribution of pathologic stages was pTis (n = 39), pT3 (n = 1), pT4a (n = 5), pT4aM1a (n = 8), and pT4aM1b (n = 11). Recurrence was observed in only 2 patients (both with pT4aM1b disease), one of whom died of disease. All remaining patients were disease-free after a median clinical follow-up of 60 months. Conclusions. Our study confirms that pTis LAMNs have an excellent prognosis and suggests that pT4a and pT4aM1a LAMNs may also have a low risk of developing progressive disease.
AB - Background. In this single-institution study, we applied the current (eighth edition) American Joint Committee on Cancer pathologic staging criteria to 64 low-grade mucinous neoplasms of the appendix (LAMNs), examined their histopathologic features, and studied the patients’ clinical outcomes. Design. Sixty-four LAMNs, with a median follow-up of 52 months, were reviewed. Results. The distribution of pathologic stages was pTis (n = 39), pT3 (n = 1), pT4a (n = 5), pT4aM1a (n = 8), and pT4aM1b (n = 11). Recurrence was observed in only 2 patients (both with pT4aM1b disease), one of whom died of disease. All remaining patients were disease-free after a median clinical follow-up of 60 months. Conclusions. Our study confirms that pTis LAMNs have an excellent prognosis and suggests that pT4a and pT4aM1a LAMNs may also have a low risk of developing progressive disease.
KW - AJCC staging
KW - LAMN
KW - TNM staging
KW - appendix
KW - low-grade appendiceal mucinous neoplasm
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U2 - 10.1177/1066896919883679
DO - 10.1177/1066896919883679
M3 - Article
C2 - 31645160
AN - SCOPUS:85074535616
SN - 1066-8969
VL - 28
SP - 252
EP - 258
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 3
ER -