Lymphocytic Colitis With Increased Apoptosis: A Marker of Mutation in T-Cell-Mediated Immunity?

Anas Bernieh, Melanie Hakar, Jerzy Stanek

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Lymphocytic colitis is a subtype of microscopic colitis that is mostly seen in adults. It presents mainly as chronic nonbloody diarrhea, with the hallmark of normal or near-normal endoscopy. In this case series, we are presenting 4 pediatric patients with lymphocytic colitis with prominent apoptosis of the colonic gland epithelium. Remarkably, all the patients have genetic mutations known to be associated with autoimmune enteropathy. Three patients have a CTLA4 mutation, and 1 patient has an STAT3 mutation. These mutations were previously reported in association with inflammatory bowel disease, but a specific connection with lymphocytic colitis has not been described. This report investigates the histopathology of such lesions in children and adolescents.

Original languageEnglish (US)
Pages (from-to)443-447
Number of pages5
JournalPediatric and Developmental Pathology
Issue number6
StatePublished - Dec 2020
Externally publishedYes


  • CTLA4
  • STAT3
  • apoptosis
  • apoptotic colopathy
  • colitis
  • lymphocytic colitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


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