Lymphoid tissue fibrosis is associated with impaired vaccine responses

Cissy Kityo; Krystelle Nganou Makamdop; Meghan Rothenberger; Jeffrey G. Chipman; Torfi Hoskuldsson; Gregory J. Beilman; Bartosz Grzywacz; Peter Mugyenyi; Francis Ssali; Rama S. Akondy; Jodi Anderson; Thomas E. Schmidt; Thomas Reimann; Samuel P. Callisto; Jordan Schoephoerster; Jared Schuster; Proscovia Muloma; Patrick Ssengendo; Eirini Moysi; Constantinos Petrovas; Ray Lanciotti; Lin Zhang; Maria T. Arévalo; Benigno Rodriguez; Ted M. Ross; Lydie Trautmann; Rafick Pierre Sekaly; Michael M. Lederman; Richard A. Koup; Rafi Ahmed; Cavan Reilly; Daniel C. Douek; Timothy W. Schacker

doi:10.1172/JCI97377

Lymphoid tissue fibrosis is associated with impaired vaccine responses

Cissy Kityo, Krystelle Nganou Makamdop, Meghan Rothenberger, Jeffrey G. Chipman, Torfi Hoskuldsson, Gregory J. Beilman, Bartosz Grzywacz, Peter Mugyenyi, Francis Ssali, Rama S. Akondy, Jodi Anderson, Thomas E. Schmidt, Thomas Reimann, Samuel P. Callisto, Jordan Schoephoerster, Jared Schuster, Proscovia Muloma, Patrick Ssengendo, Eirini Moysi, Constantinos PetrovasRay Lanciotti, Lin Zhang, Maria T. Arévalo, Benigno Rodriguez, Ted M. Ross, Lydie Trautmann, Rafick Pierre Sekaly, Michael M. Lederman, Richard A. Koup, Rafi Ahmed, Cavan Reilly, Daniel C. Douek, Timothy W. Schacker

Vaccine and Gene Therapy Institute

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Vaccine responses vary by geographic location. We have previously described how HIV-associated inflammation leads to fibrosis of secondary lymph nodes (LNs) and T cell depletion. We hypothesized that other infections may cause LN inflammation and fibrosis, in a process similar to that seen in HIV infection, which may lead to T cell depletion and affect vaccine responses. We studied LNs of individuals from Kampala, Uganda, before and after yellow fever vaccination (YFV) and found fibrosis in LNs that was similar to that seen in HIV infection. We found blunted antibody responses to YFV that correlated to the amount of LN fibrosis and loss of T cells, including T follicular helper cells. These data suggest that LN fibrosis is not limited to HIV infection and may be associated with impaired immunologic responses to vaccines. This may have an impact on vaccine development, especially for infectious diseases prevalent in the developing world.

Original language	English (US)
Pages (from-to)	2763-2773
Number of pages	11
Journal	Journal of Clinical Investigation
Volume	128
Issue number	7
DOIs	https://doi.org/10.1172/JCI97377
State	Published - Jul 2 2018

ASJC Scopus subject areas

General Medicine

Access to Document

10.1172/JCI97377

Cite this

Kityo, C., Makamdop, K. N., Rothenberger, M., Chipman, J. G., Hoskuldsson, T., Beilman, G. J., Grzywacz, B., Mugyenyi, P., Ssali, F., Akondy, R. S., Anderson, J., Schmidt, T. E., Reimann, T., Callisto, S. P., Schoephoerster, J., Schuster, J., Muloma, P., Ssengendo, P., Moysi, E., ... Schacker, T. W. (2018). Lymphoid tissue fibrosis is associated with impaired vaccine responses. Journal of Clinical Investigation, 128(7), 2763-2773. https://doi.org/10.1172/JCI97377

Kityo, C, Makamdop, KN, Rothenberger, M, Chipman, JG, Hoskuldsson, T, Beilman, GJ, Grzywacz, B, Mugyenyi, P, Ssali, F, Akondy, RS, Anderson, J, Schmidt, TE, Reimann, T, Callisto, SP, Schoephoerster, J, Schuster, J, Muloma, P, Ssengendo, P, Moysi, E, Petrovas, C, Lanciotti, R, Zhang, L, Arévalo, MT, Rodriguez, B, Ross, TM, Trautmann, L, Sekaly, RP, Lederman, MM, Koup, RA, Ahmed, R, Reilly, C, Douek, DC & Schacker, TW 2018, 'Lymphoid tissue fibrosis is associated with impaired vaccine responses', Journal of Clinical Investigation, vol. 128, no. 7, pp. 2763-2773. https://doi.org/10.1172/JCI97377

@article{04644a3406134e9290cf168d735c07dc,

title = "Lymphoid tissue fibrosis is associated with impaired vaccine responses",

abstract = "Vaccine responses vary by geographic location. We have previously described how HIV-associated inflammation leads to fibrosis of secondary lymph nodes (LNs) and T cell depletion. We hypothesized that other infections may cause LN inflammation and fibrosis, in a process similar to that seen in HIV infection, which may lead to T cell depletion and affect vaccine responses. We studied LNs of individuals from Kampala, Uganda, before and after yellow fever vaccination (YFV) and found fibrosis in LNs that was similar to that seen in HIV infection. We found blunted antibody responses to YFV that correlated to the amount of LN fibrosis and loss of T cells, including T follicular helper cells. These data suggest that LN fibrosis is not limited to HIV infection and may be associated with impaired immunologic responses to vaccines. This may have an impact on vaccine development, especially for infectious diseases prevalent in the developing world.",

author = "Cissy Kityo and Makamdop, {Krystelle Nganou} and Meghan Rothenberger and Chipman, {Jeffrey G.} and Torfi Hoskuldsson and Beilman, {Gregory J.} and Bartosz Grzywacz and Peter Mugyenyi and Francis Ssali and Akondy, {Rama S.} and Jodi Anderson and Schmidt, {Thomas E.} and Thomas Reimann and Callisto, {Samuel P.} and Jordan Schoephoerster and Jared Schuster and Proscovia Muloma and Patrick Ssengendo and Eirini Moysi and Constantinos Petrovas and Ray Lanciotti and Lin Zhang and Ar{\'e}valo, {Maria T.} and Benigno Rodriguez and Ross, {Ted M.} and Lydie Trautmann and Sekaly, {Rafick Pierre} and Lederman, {Michael M.} and Koup, {Richard A.} and Rafi Ahmed and Cavan Reilly and Douek, {Daniel C.} and Schacker, {Timothy W.}",

year = "2018",

month = jul,

day = "2",

doi = "10.1172/JCI97377",

language = "English (US)",

volume = "128",

pages = "2763--2773",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "The American Society for Clinical Investigation",

number = "7",

}

TY - JOUR

T1 - Lymphoid tissue fibrosis is associated with impaired vaccine responses

AU - Kityo, Cissy

AU - Makamdop, Krystelle Nganou

AU - Rothenberger, Meghan

AU - Chipman, Jeffrey G.

AU - Hoskuldsson, Torfi

AU - Beilman, Gregory J.

AU - Grzywacz, Bartosz

AU - Mugyenyi, Peter

AU - Ssali, Francis

AU - Akondy, Rama S.

AU - Anderson, Jodi

AU - Schmidt, Thomas E.

AU - Reimann, Thomas

AU - Callisto, Samuel P.

AU - Schoephoerster, Jordan

AU - Schuster, Jared

AU - Muloma, Proscovia

AU - Ssengendo, Patrick

AU - Moysi, Eirini

AU - Petrovas, Constantinos

AU - Lanciotti, Ray

AU - Zhang, Lin

AU - Arévalo, Maria T.

AU - Rodriguez, Benigno

AU - Ross, Ted M.

AU - Trautmann, Lydie

AU - Sekaly, Rafick Pierre

AU - Lederman, Michael M.

AU - Koup, Richard A.

AU - Ahmed, Rafi

AU - Reilly, Cavan

AU - Douek, Daniel C.

AU - Schacker, Timothy W.

PY - 2018/7/2

Y1 - 2018/7/2

N2 - Vaccine responses vary by geographic location. We have previously described how HIV-associated inflammation leads to fibrosis of secondary lymph nodes (LNs) and T cell depletion. We hypothesized that other infections may cause LN inflammation and fibrosis, in a process similar to that seen in HIV infection, which may lead to T cell depletion and affect vaccine responses. We studied LNs of individuals from Kampala, Uganda, before and after yellow fever vaccination (YFV) and found fibrosis in LNs that was similar to that seen in HIV infection. We found blunted antibody responses to YFV that correlated to the amount of LN fibrosis and loss of T cells, including T follicular helper cells. These data suggest that LN fibrosis is not limited to HIV infection and may be associated with impaired immunologic responses to vaccines. This may have an impact on vaccine development, especially for infectious diseases prevalent in the developing world.

AB - Vaccine responses vary by geographic location. We have previously described how HIV-associated inflammation leads to fibrosis of secondary lymph nodes (LNs) and T cell depletion. We hypothesized that other infections may cause LN inflammation and fibrosis, in a process similar to that seen in HIV infection, which may lead to T cell depletion and affect vaccine responses. We studied LNs of individuals from Kampala, Uganda, before and after yellow fever vaccination (YFV) and found fibrosis in LNs that was similar to that seen in HIV infection. We found blunted antibody responses to YFV that correlated to the amount of LN fibrosis and loss of T cells, including T follicular helper cells. These data suggest that LN fibrosis is not limited to HIV infection and may be associated with impaired immunologic responses to vaccines. This may have an impact on vaccine development, especially for infectious diseases prevalent in the developing world.

UR - http://www.scopus.com/inward/record.url?scp=85049859039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049859039&partnerID=8YFLogxK

U2 - 10.1172/JCI97377

DO - 10.1172/JCI97377

M3 - Article

C2 - 29781814

AN - SCOPUS:85049859039

SN - 0021-9738

VL - 128

SP - 2763

EP - 2773

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 7

ER -

Lymphoid tissue fibrosis is associated with impaired vaccine responses

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this