Macular perfusion in healthy chinese: An optical coherence tomography angiogram study

Jian Yu, Chunhui Jiang, Xiaolei Wang, Li Zhu, Ruiping Gu, Huan Xu, Yali Jia, David Huang, Xinghuai Sun

Research output: Contribution to journalArticlepeer-review

227 Scopus citations


PURPOSE. To investigate macular perfusion in healthy Chinese individuals and examine its dependence on age and sex. METHODS. Healthy adult Chinese individuals were recruited. Macular perfusion was measured by spectral-domain optical coherence tomography (OCT) using the split-spectrum amplitudedecorrelation angiography (SSADA) algorithm. The parafoveal flow index and vessel area density as well as the area of the foveal capillary-free zone (CFZ) were quantified. RESULTS. A total of 76 eyes in 45 subjects were included (20 males and 25 females, mean age 36±11 years). The mean parafoveal flow index was 0.099 ± 0.013; the mean vessel area density was 0.891 ± 0.073; and the mean CFZ area was 0.474 ± 0.172 mm2. All three parameters were significantly correlated with age (flow index: P = 0.00; vessel area density: P = 0.00; CFZ area: P = 0.02). The flow index and vessel area density decreased annually by 0.6% and 0.4%, respectively, and CFZ area increased by 1.48% annually. The CFZ area was larger in females than in males, while all three parameters seemed to change more rapidly with age in males than in females. CONCLUSIONS. In healthy Chinese eyes, macular perfusion decreased with increasing age, and decreased more rapidly in males than in females. The application of OCT angiograms may provide a useful approach for monitoring macular perfusion, although caution must be exercised with regard to age- and sex-related variations.

Original languageEnglish (US)
Pages (from-to)3212-3217
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Issue number5
StatePublished - 2015


  • Capillary-free zone
  • Macular perfusion
  • Optical coherence tomography (OCT) angiogram
  • Split-spectrum amplitudedecorrelation angiography (SSADA) algorithm

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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