Magnetic nanoparticle biodistribution following intratumoral administration

A. J. Giustini; R. Ivkov; P. J. Hoopes

doi:10.1088/0957-4484/22/34/345101

Magnetic nanoparticle biodistribution following intratumoral administration

A. J. Giustini, R. Ivkov, P. J. Hoopes

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Recently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be determined. We have used transmission electron microscopy (TEM) to define the time dependent cellular uptake of intratumorally administered dextran-coated, core-shell configuration IONP having a mean hydrodynamic diameter of 100-130nm in a murine breast adenocarcinoma cell line (MTG-B) invivo. Tumors averaging volumes of 115mm³ were injected with iron oxide nanoparticles. The tumors were then excised and fixed for TEM at time 0.1-120h post-IONP injection. Intracellular uptake of IONPs was 5.0, 48.8 and 91.1% uptake at one, 2 and 4h post-injection of IONPs, respectively. This information is essential for the effective use of IONP hyperthermia in cancer treatment.

Original language	English (US)
Article number	345101
Journal	Nanotechnology
Volume	22
Issue number	34
DOIs	https://doi.org/10.1088/0957-4484/22/34/345101
State	Published - Aug 26 2011
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Mechanics of Materials
Mechanical Engineering
Electrical and Electronic Engineering

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10.1088/0957-4484/22/34/345101

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title = "Magnetic nanoparticle biodistribution following intratumoral administration",

abstract = "Recently, heat generated by iron oxide nanoparticles (IONPs) stimulated by an alternating magnetic field (AMF) has shown promise in the treatment of cancer. To determine the mechanism of nanoparticle-induced cytotoxicity, the physical association of the cancer cells and the nanoparticles must be determined. We have used transmission electron microscopy (TEM) to define the time dependent cellular uptake of intratumorally administered dextran-coated, core-shell configuration IONP having a mean hydrodynamic diameter of 100-130nm in a murine breast adenocarcinoma cell line (MTG-B) invivo. Tumors averaging volumes of 115mm3 were injected with iron oxide nanoparticles. The tumors were then excised and fixed for TEM at time 0.1-120h post-IONP injection. Intracellular uptake of IONPs was 5.0, 48.8 and 91.1% uptake at one, 2 and 4h post-injection of IONPs, respectively. This information is essential for the effective use of IONP hyperthermia in cancer treatment.",

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AU - Ivkov, R.

AU - Hoopes, P. J.

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Magnetic nanoparticle biodistribution following intratumoral administration

Abstract

ASJC Scopus subject areas

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