Magnetic nanoparticle hyperthermia enhancement of cisplatin chemotherapy cancer treatment

Purpose: The purpose of this study was to examine the therapeutic effect of magnetic nanoparticle hyperthermia (mNPH) combined with systemic cisplatin chemotherapy in a murine mammary adenocarcinoma model (MTGB). Materials and methods: An alternating magnetic field (35.8kA/m at 165kHz) was used to activate 110nm hydroxyethyl starch-coated magnetic nanoparticles (mNP) to a thermal dose of 60min at 43C. Intratumoral mNP were delivered at 7.5mg of Fe/cm³ of tumour (four equal tumour quadrants). Intraperitoneal cisplatin at 5mg/kg body weight was administered 1h prior to mNPH. Tumour regrowth delay time was used to assess the treatment efficacy. Results: mNP hyperthermia, combined with cisplatin, was 1.7 times more effective than mNP hyperthermia alone and 1.4 times more effective than cisplatin alone (p<0.05). Conclusions: Our results demonstrate that mNP hyperthermia can result in a safe and significant therapeutic enhancement for cisplatin cancer therapy.